P155 A retrospective analysis of
Clostridium difficile infection in patients with ulcerative colitis
Xu H.*1, Li Y.1, Xu T.2, Li J.1, Yang H.1, Lv H.1, Qian J.1
1Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Department of Gastroenterology, Beijing, China 2Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Depatment of Epidemiology and Biostatistics, Beijing, China
Many reports have documented the increasing impact of
Patients with UC, hospitalized from January 2010 to December 2015 at the department of gastrointestinal in PUMCH, China were objects of this study. For all the patients suspected of CDI, stool samples were tested for toxins A and B of
In a total of 421 in-patients with UC, 34 (8.08%) were CDAB positive and diagnosed as CDI. 68 CDAB negative patients were matched. Univariate analyses revealed that risk factors for CDI were: antibiotic exposure within 3 months prior to CDAB test (p=0.004), prior hospitalization within 1 month (p=0.025), systemic use of steroids (p=0.002), and dose of steroids used in CDI patients was higher than non-CDI patients (p=0.001). At the meanwhile, the study found a correlation between active cytomegalovirus (CMV) infection and CDI in UC patients (p=0.001). On logistic regression analyses, active CMV infection had a significant difference between CDI and non-CDI patients (OR 13.502, 95% CI: 1.307∼139.512, p=0.029). However, the severity of UC (evaluated on clinical criteria and endoscopic scoring system), distribution of UC, disease course, duration of disease, history of smoking and alcohol use, combination of diabetes, history of surgery, 5-aminosalicylic acid (5-ASA), proton pump inhibitor (PPI), immunosuppressants except steroids, infliximab, parenteral nutrition within 1 month didn't increase the risk of CDI in UC patients. Clinical features of CDI patients in UC had no significant differences from non-CDI patients, such as body mass index (BMI), defecation frequency, toxic megacolon incidence rate, leucocyte and neutrocyte level of peripheral blood (p≥0.05). CDI didn't increase the subsequent colectomy rate in this study.
The complication of IBD by