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P232 Atherosclerosis in ulcerative colitis

Popa I.V.*1,2, Gavrilescu O.1,2, Popa R.C.2, Dranga M.1,2, Didita A.2, Jigaranu A.O.1,2, Ungureanu I.O.1,2, Mihai C.1,2, Cijevschi-Prelipcean C.1,2

1Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania 2St Spiridon Hospital, Department of Gastroenterology, Iasi, Romania

Background

To study the extent of early atherosclerosis in ulcerative colitis (UC) patients by measuring carotid intima–media thickness in UC. Our goal was to evaluate a possible connection between early atherosclerosis and ulcerative colitis (UC) evolution.

Methods

Our study included 120 patients (after excluding the patients with risk factors for atherosclerosis) divided in two groups: 60 with UC and 60 controls. Both groups had similar age distribution. For each patient included in the study we measured the carotid intima–media thickness, lipid profile (to exclude patients with risk factors), erythrocyte sedimentation rate (ESR), C reactive protein (CRP). We also collected clinical and anamnesis data.

Results

The carotid intima–media thickness was significantly higher in UC group compared with healthy subjects (p=0.048). In addition, we found significant correlations between some disease-related data (such as UC duration) and the values of carotid intima–media thickness (p<0.01). UC patients had significantly higher ESR and CRP (p<0.05).

Conclusion

In this study we showed that UC may have an influence on early atherosclerosis formation, but further studies are needed to determine the pathophysiological mechanisms.