P259 The clinical course of ulcerative colitis after orthotopic liver transplantation in context of HLA-DR mismatch
Bajer L., Slavcev A., Macinga P., Roder M., Brezina J., Trunecka P., Spicak J., Drastich P.
Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Primary sclerosing cholangitis (PSC) is a chronic liver disorder of unknown etiology, characterized by inflammation, fibrosis and stenoses of both extra- and intrahepatic bile ducts. For those who develop end – stage liver disease, orthotopic liver transplantation (OLT) remains the only effective treatment currently available. PSC is accompanied with concomitant ulcerative coilitis (UC) in a significant proportion of patients. Benefits of routine HLA (human leukocyte antigen) typing in donor and recipient prior to OLT were proved in the past. The aim of this study was to assess the impact of HLA-DR mismatch on
We retrospectively evaluated records of 57 patients transplanted at Institute for Clinical and Experimental Medicine (Prague, Czech Republic) between July 1994 and November 2011. Only patients with proper records (including regular colonoscopy) ± 5 years from OLT were included. We evaluated likelihood for each variable (course pre-OLT UC,
Out of 57 patients, 27 (47.4%) had single mismatch and 30 (53.6%) had double mismatch in HLA-DR. No patient had full match. 12/57 (21.1%) had
Patients with single mismatch in HLA-DR have slight tendency towards worsening of pre-existing UC after OLT as compared to patients with double mismatch. Analysis of combined mismatch in HLA-DR and HLA-DQ could demonstrate more substantial linkages in respective clinical variables. Therefore, these data have to be considered as preliminary as typing for HLA-DQ from frozen blood samples is currently underway.
Supported by Ministry of Health of the Czech Republic, grant nr. 15-28064A. All rights reserved.