P344 Vitamin D-Induced alterations in Cytokine levels lower the risk of clinical relapse in ulcerative colitis
Gubatan J.M., Mitsuhashi S., Longhi M.S., Zenlea T., Rosenberg L., Robson S., Moss A.
Beth Israel Deaconess Medical Center, Harvard Medical School, Division of Gastroenterology, Department of Medicine, Boston, United States
Vitamin D has immunomodulatory effects
The effects of 1,25-hydroxyvitamin D on cytokine mRNA and protein levels were evaluated in human colonic epithelial cells (DLD1) challenged with lipopolysaccharide
Vitamin D (10 nM) stimulated increased IL-10, and decreased TNF-α, levels in colonic epithelial cells
This ratio (IL-4+IL-10/IL-6+TNF-α) was higher at baseline among patients who remained in clinical remission over 12 months (mean 24 in remitters vs 13 in relapsers, p<0.05).
This association with future risk of clinical relapse persisted when endoscopic and histological inflammation at baseline were controlled for in a multivariate model (O.R. 0.7, 95% CI 0.6–0.9, p=0.003).
Vitamin D induces an anti-inflammatory cytokine profile that is more prevalent in patients with UC who exhibit sustained clinical remission. Such immunomodulatory properties warrant further examination for therapeutic potential.