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* = Presenting author

P572 Medical therapies for stricturing Crohn's disease: efficacy and cross-sectional imaging predictors of therapeutic failure

Campos C.1, Perrey A.2, Lambert C.3, Pereira B.3, Goutte M.1,4, Goutorbe F.1,5, Dubois A.6, Reymond M.1, Allimant C.1, Dapoigny M.1, Bommelaer G.1,4, Hordonneau C.2, Buisson A.*1,4

1University Hospital Estaing, Gastroenterology Department, Clermont-Ferrand, France 2University Hospital Estaing, Radiology Department, Clermont-Ferrand, France 3University Hospital, Biostatistics Unit, DRCI, Clermont-Ferrand, France 4UMR 1071 Inserm/Université d'Auvergne; USC-INRA 2018, Microbes, Intestine, Inflammation and Susceptibility of the host, Clermont-Ferrand, France 5Hospital of Bayonne, Gastroenterology Department, Bayonne, France 6CHU Estaing, Department of Digestive surgery, Clermont-Ferrand, France

Background

Medical therapy efficacy remains controversial in stricturing Crohn's disease.

In the present study, we aimed to assess the long-term impact of medical therapies in stricturing CD and to identify both the clinical and radiological factors associated with long-term therapeutic failure in patients receiving medical treatments for stricturing CD. In addition, we aimed to assess the factors associated with short-term clinical response in stricturing CD.

Methods

In this retrospective study, therapeutic failure was defined as symptomatic stricture leading to surgical or endoscopic therapeutics, hospitalization, treatment discontinuation or additional therapy. The short-term clinical response was defined as clinical improvement based on obstructive pain intensity, associated signs such as nausea and vomiting or dietary restrictions assessed by two IBD physicians between week 12 and week 24. The 55 cross-sectional imaging examinations (33MRI, 22CT-scan) before starting medical therapy were analyzed independently by two radiologists.

Results

Overall, 84 patients were included in the study. Their characteristics at the time of inclusion are given in Table 1.

Table 1. Baseline characteristics and factors associated with therapeutic failure (univariate analysis) in a cohort of 84 patients receiving medical therapy for stricturing Crohn's disease

Among them, therapeutic failure rate within 60 months was 66.6%. In multivariate analysis, Crohn's disease diagnosis after 40 years-old (HR = 3.9 95% CI [1.37–11.2], p=0.011), small stricture luminal diameter (HR = 1.34 95% CI [1.01–1.80], p=0.046), increased stricture wall thickness (HR = 1.23 95% CI [1.04–1.46], p=0.013), and fistula with abscess (HR = 5.63 95% CI [1.64–19.35] p=0.006) were associated with therapeutic failure while anti-TNF combotherapy (HR = 0.17 95% CI [0.40–0.71], p=0.015) prevented it. Considering 108 therapeutic sequences, the short-term clinical response rate was 65.7%. In multivariate analysis, male gender (OR = 0.15 95% CI [0.03–0.64], p=0.011), fistula with abscess (OR = 0.09 95% CI [0.01–0.77], p=0.028) and comb sign (OR = 0.23 95% CI [0.005–0.97], p=0.047) were associated with short-term clinical failure.

Conclusion

Anti-TNF combotherapy seemed to be the best long-term therapeutic option in stricturing CD. Some morphological characteristics of the stenosis independent from the inflammation/fibrosis dichotomy as well as some factors reflecting inflammation and/or fibrosis retrieved from cross-sectional imaging are predictive of therapeutic failure in stricturing CD. Cross-sectional imaging especially MRI should be performed before starting medical therapy in CD with stenosis as it is very helpful to guide therapeutic decision-making.