P697 Association of inflammatory bowel disease and celiac disease. Experience in a hospital of the autonomous community of Madrid (Spain)
Manceñido Marcos N.*1, Pajares Villarroya R.1, Salinas Moreno S.2, Arribas Lόpez M.R.1, Comas Redondo C.1
1Hospital Universitario Infanta Sofía, Gastroenterology Department, San Sebastián de los Reyes (Madrid), Spain 2Hospital Universitario Infanta Sofía, Pathology Department, San Sebastián de los Reyes (Madrid), Spain
There are multiple and controversial data about the relationship between Celiac Disease (CeD) and Inflammatory Bowel Disease (IBD).
We pretend to study the prevalence of CeD in patients diagnosed
CeD screening was performed in newly diagnosed IBD patients by the determination of blood levels of IgA and IgA tissue transglutaminase antibodies (anti-tTG) (in case of IgA deficiency, IgA levels wth high sensitivity techniques or levels of IgG anti-tTG were determined). In those patients with positive anti-tTG, an endoscopic duodenal biopsy and a genetic test of CeD susceptibility (HQ DQ2/ DQ8 heterodimers) were performed.
None of the patients had received steroids or immunosuppressive or biological drugs in the three months prior to endoscopy. Celiac disease was diagnosed in patients with positive anti-tTG, a compatible duodenal biopsy, and good response to a gluten-free diet.
The prevalence of celiac disease in our group was compared with the expected prevalence in the general population according to published adult series of national studies.
CeD screening was performed in 163 patients with
In all patients with CeD and IBD, IgA was in a normal range, anti-tTG were positive, and all of them had positive CeD genetic markers, and none of them had family history of CeD.
The prevalence of CeD in our group of patients with IBD is 2.45% (4/163 patients), 3 with UC and 1 with CD.
In our group of patients with