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P722 Prediagnostic serum vitamin D levels and risk of inflammatory bowel disease: a pan-European, nested case-control study

Opstelten J.*1, Chan S.2,3, Hart A.2,3, van Schaik F.1, Siersema P.4, Lentjes E.5, Khaw K.-T.6, Luben R.6, Key T.7, Boeing H.8, Bergmann M.8, Overvad K.9, Palli D.10, Masala G.10, Racine A.11,12, Carbonnel F.11,12, Boutron-Ruault M.-C.11, Tjønneland A.13, Olsen A.13, Andersen V.14, Kaaks R.15, Kühn T.15, Tumino R.16, Trichopoulou A.17, Verschuren M.18,19, Witteman B.20,21, Oldenburg B.1

1University Medical Centre Utrecht, Department of Gastroenterology and Hepatology, Utrecht, Netherlands 2University of East Anglia, Norwich Medical School, Department of Medicine, Norwich, United Kingdom 3Norfolk and Norwich University Hospitals NHS Foundation Trust, Department of Gastroenterology, Norwich, United Kingdom 4Radboud University Medical Centre, Department of Gastroenterology and Hepatology, Nijmegen, Netherlands 5University Medical Centre Utrecht, Department of Clinical Chemistry and Haematology, Utrecht, Netherlands 6University of Cambridge, Institute of Public Health, Strangeways Research Laboratory, Cambridge, United Kingdom 7University of Oxford, Nuffield Department of Population Health, Cancer Epidemiology Unit, Oxford, United Kingdom 8German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Department of Epidemiology, Nuthetal, Germany 9Aarhus University, Department of Public Health, Section for Epidemiology, Aarhus, Denmark 10Cancer Research and Prevention Institute (ISPO), Molecular and Nutritional Epidemiology Unit, Florence, Italy 11Institut Gustave Roussy, French Institute of Health and Medical Research (Inserm), Center for Research in Epidemiology and Population Health, Villejuif, France 12Université Paris-Sud, Assistance Publique Hôpitaux de Paris, University Hospital of Bicêtre, Department of Gastroenterology, Le Kremlin Bicêtre, France 13Danish Cancer Society Research Center, Unit of Diet, Genes and Environment, Copenhagen, Denmark 14University of Southern Denmark, Institute of Regional Research-Center Sønderjylland, Odense, Denmark 15German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany 16“Civic–M.P. Arezzo” Hospital, Cancer Registry and Histopathology Unit, Ragusa, Italy 17Hellenic Health Foundation, Athens, Greece 18University Medical Center Utrecht, Julius Centre for Health Sciences and Primary Care, Utrecht, Netherlands 19National Institute for Public Health and the Environment (RIVM), Centre for Nutrition, Prevention and Health Services, Bilthoven, Netherlands 20Gelderse Vallei Hospital, Department of Gastroenterology and Hepatology, Ede, Netherlands 21Wageningen University, Division of Human Nutrition, Wageningen, Netherlands


A causal link between a low vitamin D status and the development of inflammatory bowel disease (IBD) has previously been suggested. The aim of this study was to investigate the association between prediagnostic circulating vitamin D concentrations and dietary intakes of vitamin D, and the risk of Crohn's disease (CD) and ulcerative colitis (UC).


Among 359,728 participants of the European Prospective Investigation into Cancer and Nutrition cohort, individuals who developed CD or UC after enrolment were identified. Each case was matched with two controls by center, gender, age, date of recruitment and follow-up time. At cohort entry, blood samples were collected and dietary vitamin D intakes were obtained from validated food frequency questionnaires. Serum 25-hydroxyvitamin D levels were measured using liquid chromatography-tandem mass spectrometry. Conditional logistic regression was performed to determine the odds of CD and UC.


Seventy-two participants developed CD and 169 participants developed UC after a median follow-up of 4.7 and 4.1 years, respectively. The median serum vitamin D level was 59.1 nmol/L for CD cases and 60.1 nmol/L for their controls. The corresponding values for UC cases and their controls were 54.2 nmol/L and 54.9 nmol/L, respectively. Compared with the lowest quartile, no associations with the three higher quartiles of vitamin D concentrations were observed for CD (p trend =0.34) or UC (p trend =0.66). Similarly, no associations were detected when serum vitamin D levels were analyzed as a continuous variable. Dietary vitamin D intakes were not associated with CD (p trend =0.39) or UC (p trend =0.83).


Vitamin D status was not associated with the development of CD or UC. These findings do not suggest a major role for vitamin D deficiency in the etiology of IBD.