P755 NUDT15 polymorphism is associated with thiopurine-related leukopenia independently of 6-thioguanine nucleotide levels in Korean paediatric inflammatory bowel disease patients
Kang B.*1, Choi J.Y.1, Lee K.1, Lee S.-Y.2, Ahn S.H.3, Lee H.J.4, Choe Y.H.1
1Samsung Medical Center, Sungkyunkwan University School of Medicine, Department of Pediatrics, Seoul, South Korea 2Samsung Medical Center, Sungkyunkwan University School of Medicine, Department of Laboratory Medicine and Genetics, Seoul, South Korea 3Samsung Medical Center, Biostatistics and Clinical Epidemiology Center, Seoul, South Korea 4Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Department of Pediatrics, Changwon, South Korea
Polymorphisms in the
This retrospective study was conducted in 167 paediatric IBD patients who had performed
NUDT15 groups of normal, intermediate, and low activity consisted of 71% (119/167), 27% (45/167), and 2% (3/167) of the enrolled subjects, respectively. Leukopenia was observed in 16% (19/119), 44% (20/45), and 100% (3/3) of the normal, intermediate, and low activity groups (p<0.001), and early leukopenia (within 8 weeks from AZA initiation) in 1% (1/119), 2% (1/45), and 100% (3/3) of each group, respectively (p<0.001).
Among patients with leukopenia, 6-TGN levels were significantly lower in patients with low activity compared to intermediate activity (median 91.8 vs. 365.6, p=0.025) and to normal activity (median 91.8 vs. 308.3 pmol/8×108 RBC, p=0.024).
According to multivariable logistic regression,
- Posted in: Poster presentations: Genetics (2017)