P855 Vegetarian and gluten-free diet in patients with IBD—associated with a different microbiota compared with omnivore IBD patients
P. Schreiner1*, B. Yilmaz2, Y. Franc3, J.-B. Rossel3, B. Misselwitz1, M. Scharl1, J. Zeitz4, P. Frei5, T. Greuter1, S. Vavricka6, V. Pittet3, A. Siebenhüner7, P. Juillerat8, R. von Känel9, A. Macpherson2, G. Rogler1, L. Biedermann1
1UniversityHospital of Zurich, Gastroenterology and Hepatology, Zurich, Switzerland, 2University of Bern, Department of Clinical Research Gastroenterology and Mucosal Immunology, Bern, Switzerland, 3Lausanne University Hospital, Institute of Social and Preventive Medicine, Lausanne, Switzerland, 4Klinik Hirslanden, Center of Gastroenterology, Zurich, Switzerland, 5Gastroenterology Bethanien, Zurich, Switzerland, 6Center of Gastroenterology and Hepatology, Zurich, Switzerland, 7UniversityHospital of Zurich, Hematology and Oncology, Zurich, Switzerland, 8Inselspital Bern University Hospital, Department of Visceral Surgery and Medicine, Bern, Switzerland, 9Clinic Barmelweid, Department of Psychosomatic Medicine, Barmelweid, Switzerland
Several studies demonstrate a lower diversity in the gut microbiota of patients with inflammatory bowel disease (IBD). Microbial alterations induced by dietary changes are amongst the key suspected responsible environmental factors to promote an increase in the incidence of IBD, and may adversely impact the course of established disease. Subsequent to our already presented results of lower psychosocial wellbeing in vegetarian diet (VD) and gluten-free diet (GFD) IBD patients (Poster 711, ECCO 2017) we investigated comparative microbial composition of IBD patients according to diet.
Dietary pattern was analysed in a total of 1656 IBD patients from the Swiss Inflammatory Bowel Disease Cohort Study between 2006 and 2015. Microbiota composition was analysed in 149 patients, including 12 vegetarian patients and 14 patients following a GFD by means of high-throughput sequencing. Within the majority of meat-eating patients, we further compared the microbiota of the low vs. high-meat-intake patients (i.e. ≤ 4 vs. >4 days per week).
In the alpha diversity analysis (Shannon) we observed a significant difference between GFD and meat-eating Crohn’s disease (CD) patients with lower species richness in meat-eating patients (
The gut microbiota composition in meat-eating IBD patients is significantly different compared with those following a VD or GFD. The potentially anti-inflammatory taxa Faecalibacterium and Butyricimonas were reduced and the inflammatory taxa Erysipelotrichaceae and Enterococcus were increased in the high-meat-intake CD patients. Our results demonstrate several bacterial changes in regularly meat-eating IBD patients compared with VD or GFD, specifically lower species richness with a dose–response effect in meat-eating CD patients.