P141 Faecal calprotectin correlates to UCEIS and can predict short-term recurrence in patients with ulcerative colitis
M. Naganuma*1, T. Kobayashi2, T. Kanai1
1Division of Gastroenterology and Hepatology, Keio University, Tokyo, Japan, 2Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan
We recently reported that ulcerative colitis Index of Severity (UCEIS) of 0–1 is associated with better long-term prognosis while faecal calprotectin is a valuable biomarker for assessing the severity of UC. However, there have been only few large multi-centre cohort studies trying to predict short-term recurrences using faecal calprotectin (FCP).
The multi-centre prospective cohort study was conducted in 756 UC patients from 14 Japanese academic institutions. Median FCP level on each score of UCEIS (range 0–7) was calculated (Cohort 1) and the correlation between FCP and UCEIS was assessed using Kruskal–Wallis analysis. We also assessed the association of FCP level and clinical recurrence (partial Mayo score>2) in quiescent UC patients (partial Mayo score of 0–1) using the log-rank test and cox proportional hazard model(Cohort 2). A receiver-operating characteristic curve analysis was conducted to determine the cut-off value of the FCP at baseline for predicting mucosal healing and clinical recurrence. FC was measured by Fluoro Enzyme Immunoassay using EliA Calprotectin 2.
The median FCP level increased gradually as UCEIS become higher (
FCP levels are strongly correlated to UCEIS and appears to be predictors of both short- and middle-term of recurrence in quiescent UC patients.