P142 Ulcerative colitis: risk factors for relapse in clinical remission patients
C. Arieira*1,2,3, H. Guimarães2, F. Dias de Castro1,2,3, M. J. Moreira1,2,3, J. Cotter1,2,3
1Hospital da Senhora da Oliveira, Gastroenterology, Guimarães, Portugal, 2Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga/Guimarães, Portugal, 3ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
Ulcerative colitis (UC) is a chronic inflammatory bowel disease, characterised by periods of remission and relapse. The aim of this study was to identify factors associated with a higher risk of relapse in patients in clinical remission.
Retrospective study, including UC patients in clinical remission with minimum follow-up of 2 years. Clinical relapse was defined as a need for therapeutic escalation and UC-related hospitalisation or surgery. Statistical analysis was carried out by means of t-test and chi-square (univariate analysis) and logistic regression (multi-variate analysis). A
In total, 169 patients were included, 51.5% female. Clinical relapse was observed in 30.2% of the patients. In the univariate analysis, relapse was more frequent in patients with higher number of previous relapses (2.7 vs. 1.0;
Presented results suggest that therapeutic non-adherence and MES at clinical remission may be helpful factors in identifying patients with inactive clinical disease at a higher risk of disease relapse.