P144 Correlation between clinical, endoscopic, histological activity scores in a cohort of patients with ulcerative colitis: a prospective study
B. Neri*1, S. Romeo1, F. Zorzi1, E. De Cristofaro1, E. Calabrese1, E. Grasso1, G. Palmieri2, L. Biancone1
1University of Rome 'Tor Vergata', Gastroenterology, Rome, Italy, 2University or Rome 'Tor Vergata', Anatomopathology, Rome, Italy
The relationship between clinical, endoscopic and histological scores used in ulcerative colitis (UC) is debated. Primary aim was to assess, in a prospective study, the correlation between clinical, endoscopic, and histological scores of activity in a cohort of UC patients undergoing colonoscopy. Secondary aim was to assess the role of histological scores in clinical practice.
From February 2016 to February 2017 UC patients undergoing colonoscopy according to clinical indication were enrolled. Inclusion criteria: (1) diagnosis of IBD; (2) age> 18, <80 years; (3) regular follow-up; (4) indication for colonoscopy. During colonoscopy ≥2 biopsies were taken from ≥1 macroscopically involved area and, possibly, from ≥1 uninvolved area. All colonoscopies were performed by the same IBD-dedicated gastroenterologist. Clinical activity was assessed with Mayo partial score (activity ≥3),1 endoscopic activity with the Mayo endoscopic score (activity ≥2).1 Histological activity was assessed by the same IBD-dedicated pathologist using the Geboes Simplified Score for UC (activity ≥3.1).2 Scores were blindly assessed. Follow-up was planned at 1 year. Data expressed as median [range]; coefficient of correlation; T-test.
UC cohort included 91 patients (M 52 [57%], age 51 [24–80] years, UC duration 15 years [1–48] years). UC extent was
In a prospective study, significant correlation was observed between clinical, endoscopic and histological activity in UC. Histological activity observed in UC patients in endoscopic remission may represent a predictive marker of clinical relapse.
Correlation between clinical and endoscopic, endoscopic and histological, clinical and histological activity scores
1. Schroeder KW, Tremaine WJ, Ilstrup DM. Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis.
2. Jauregui-Amezaga A, Geerits A, Das Y