P190 Anaemia and iron deficiency in a tertiary IBD centre in Brazil: prevalence and significancy
R. S. Parra*1, M. R. Feitosa1, S. C. Ferreira2, R. S. Rodrigues1, A. Favoretto Jr1, B. E. Caetano1, O. Féres1, J. J. Ribeiro da Rocha1, L. E. d. A. Troncon2
1Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil, Surgery and Anatomy, Ribeirão Preto, SP, Brazil, 2Ribeirão Preto Medical School, University of São Paulo, Division of Gastroenterology, Department of Medicine, Ribeirão Preto – SP, Brazil
Anaemia and iron deficiency anaemia (IDA) has been known to cause significant functional impairment, lower quality of life, higher morbidity and mortality. The aim of this study was to estimate the prevalence and significance of anaemia and IDA in patients with IBD in a tertiary IBD unit in Southeast Brazil
Retrospective analysis from the adult population‐based IBD cohort of Clinical Hospital of Ribeirão Preto Medical School, University of São Paulo, Brazil, consisting of 579 patients, between January 2014 through July 2018. Medical records consisted of haemoglobin measurements and serum ferritin extracted from the hospital data system. We also compared the phenotype in Crohn's disease (CD) and the extension of ulcerative colitis (UC) with the anaemia prevalence. WHO criteria defined anaemia. IDA was evaluated using ferritin and C reactive protein (CRP).
Of 579 patients, 529 had complete blood count available at medical records and 205 patients had IDA calculated. Means that during this 4-year median follow-up period, only 35.5% of patients with IBD (41.5% in CD and 35.2% in UC) were fully screened for anaemia. Table 1 summarises the patient’s characteristics.
Table 1. Patient’s characteristics (
|Mean age (years)||45.4|
|Anaemia in ulcerative colitis (UC) (%)||19.1|
|Anaemia in Crohn’s disease (CD) (%)||29.1|
|Moderate to severe anaemia (UC) (%)||11.4|
|Moderate to severe anaemia (CD) (%)||19.8|
|Iron deficiency anaemia (UC) (%)||57.2|
|Iron deficiency anaemia (CD) (%)||53.6|
CD was associated with an increased prevalence of anaemia (
|Variable||OR; CI 95%|
|Penetrant disease phenotype (CD)||0.25 (0.14–0.43)||<0.0001|
|Active disease (IBD)||2.61 (1.56–4.36)||0.0003|
|CD who underwent surgical resection||0.24 (0.14–0.40)||<0.0001|
Factors associated with higher/lower risk of anaemia. IBD = inflammatory bowel disease; CD = Crohn's disease.
Anaemia is a common manifestation of IBD. However, screening for anaemia and, in particular, iron deficiency, are rarely performed. CD is associated with an increased risk of anaemia, especially with active disease.1
1. Eriksson C, Henriksson I, Brus O,