P206 Colectomy rate in paediatric patients with ulcerative colitis is decreasing
Z. Misak*1, I. Trivic1, M. Masic1, O. Jadresin1, S. Kolacek1, I. Hojsak1
1Children's Hospital Zagreb, Zagreb, Croatia
Paediatric-onset ulcerative colitis (UC) is often more extensive than in adults, and as disease severity is associated with disease extent, children are more prone to refractory severe episodes, sometimes requiring colectomy. Previous population-based studies in patients with UC revealed variable colectomy rates. However, a decrease in colectomy rates was observed during the last two decades. The aim of our study was to assess the colectomy rate in paediatric patients with UC and to compare the clinical features of children who had to those who did not have colectomy.
In our hospital, data on children diagnosed with inflammatory bowel disease have been prospectively collected since January 2004. Retrospectively we analysed data (including disease history, baseline characteristics, and course of disease) on all children diagnosed with UC (
Of 166 children diagnosed with UC, 12 had colectomy (7.2%). When compared with UC patients who did not have colectomy, patients with colectomy did not significantly differ in gender (girls 58% vs. 48%), age at diagnosis (12.27 vs. 12.62 years), body mass index at the time of diagnosis (median −1.2 vs. −0.22), Paediatric Ulcerative Colitis Activity Index (PUCAI) at the diagnosis (median 32.5 vs. 40), proportion of patients with extensive disease (E4) (75% vs. 57%) nor in extraintestinal manifestations. However, there was a significant difference in family history positive to IBD (25% vs. 7%,
Our paediatric patients presented with extensive form of the ulcerative colitis in nearly 60% of patients, requiring colectomy in overall 7.2% of patients. However, the colectomy rate decreased significantly during the observed period.