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P236 Inflammatory bowel disease epidemiology a tertiary centre in Brazil

R. S. Parra*1, M. R. Feitosa1, S. C. Ferreira2, B. E. Caetano1, A. FavorettoJr1, J. J. Ribeiro da Rocha1, O. Féres1, L. E. d. A. Troncon2

1Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil, Surgery and Anatomy, Ribeirão Preto, SP, Brazil, 2Ribeirão Preto Medical School, University of São Paulo, Division of Gastroenterology, Department of Medicine, Ribeirão Preto - SP, Brazil

Background

Data regarding the prevalence of inflammatory bowel disease (IBD) are scarce in Brazil. The aim of this study was to determine the prevalence of IBD and to analyse the demographical, clinical phenotipes of these cases in a tertiary IBD Unity in Southeast Brazil.

Methods

Retrospective analysis from the adult population‐based IBD cohort of Clinical Hospital of Ribeirão Preto Medical School, University of São Paulo, Brazil, between 2014 and 2018. Medical records consisted in age, gender, occupation, disease (Crohn’s disease [CD]; ulcerative colitis [UC]), disease location, moderate-to-severe feature, previous surgeries, treatments, and biological therapy.

Results

Of 579 patients, 325 had CD and 254 had UC. Fifty-three (53%) were females. Mean age at diagnosis was 32.4 years. Eighty-two per cent of patients were moderate to severe. The mean time of disease was 159 months (13.25 years). Two hundred and two patients (n = 272) are in the use of biological therapy. The distribution of CD cases in relation to location was: L3 (54.8%), L1 (29.1%), L2 (15.2%), and L4 (0.9%) and the behaviour was; B1 (26.3%), B2 (12.7%), B3 (20.1%), B3P (31.9%), B2 / B3 (4.6%) and B2 / B3P (4.3%).In the UC the distribution of the cases in relation to the location was; E3 (53.1%), E2 (26%) and E1 (20.9%). Table 1 summarises the results in UC and CD. Female was more frequently in UC (60.6% vs. 47.4%, p = 0.0019; OR = 0.5848; CI 95%: 0.419–0.815). Biological therapy was more frequently in CD (64.3% vs. 26.0%, p < 0.0001; OR = 5.064; C1 95%: 3.531–7.262). Previous surgeries (59.1% vs. 19.7%, p < 0.0001; OR = 5.89; C1 95%: 4.027–8.615) and deaths (2.8% vs. 0%) were more common in CD.

VariableCD (n = 325)UC (n = 254)
Female154 (47.4%)154 (60.6%)*
Age at diagnosis (years)30.434.81
Disease duration (months)166.5149.7
Biological therapy208 (64%)*66 (26%)
Previous surgeries192 (59.1%)*50 (19.7%)
Cancer5 (1.54%)2 (0.79%)
Cholangitis7 (2.2%)11 (4.3%)
Deaths9 (2.8%)0 (0%)
Employed195 (47.4%)129 (50.8%)

Clinical features in UC and CD. *Statistical significantly.

Conclusion

There was a predominance of patients with CD in our IBD Unit. Most of UC patients were female. CD was associated with higher risk of surgery, biological therapy and death.1,2

References

1. Lima Martins A, Volpato RA, Zago-Gomes MDP. The prevalence and phenotype in Brazilian patients with inflammatory bowel disease. BMC Gastroenterol 2018;18:8, doi:10.1186/s12876-018-0822-y

2. Gasparini R, Sassakji LY, Saad-Hossne R. Inflammatory bowel disease epidemiology in São Paulo State, Brazil. Clin Exp Gastroenterol 2018;11:423–9.