P243 The different role of histology in ulcerative colitis and Crohn’s disease: a retrospective study in a single referral centre
C. Pagnini*1, M. C. Di Paolo1, D. Campagna2, L. Costarelli2, F. Monardo2, F. R. Piro2, L. D'Alba1, M. A. De Cesare1, L. Pallotta1, R. Urgesi1, G. Villotti1, M. A. Vitale1, M. Giordano2, M. G. Graziani1
1S. Giovanni Addolorata Hospital, Gastroenterology and Digestive Endoscopy, Rome, Italy, 2S. Giovanni Addolorata Hospital, Anatomy and Pathological Histology, Rome, Italy
In addition to endoscopic evaluation, a consistent set of studies has demonstrated an important role for histology in ulcerative colitis (UC) patients, both for diagnosis and in follow-up, while in Crohn’s disease (CD) evidence are scantier. The aim of the study was to investigate the different role of histological evaluation in CD and UC patients, in a single referral centre.
Data of 86 IBD patients in follow-up at IBD Outpatient Clinic in San Giovanni-Addolorata Hospital in Rome (2016–2017) were retrospectively evaluated. We included only patients (
In patients in follow-up, a significant higher rate of UC patients showed full concordance (specificity and activity) between histological and endoscopic evaluation comparing with CD patients [26/30(87%) vs. 12/30(40%),
in UC patients, histological evaluation consistently correlated with endoscopic and clinical features of active disease, and showed an elevated specificity both for the diagnosis and in the follow-up. In CD patients, correlation with histology and endoscopic/clinical features was less impressive. In a referral centre histological evaluation has a potential relevant role in IBD diagnosis and follow-up.