P250 Use of complementary and alternative medicine is associated with chronic fatigue and lower health-related quality of life in patients with inflammatory bowel disease 20 years after diagnosis: results from the IBSEN study
R. Opheim*1,2, J. Jahnsen2,3, G. Huppertz-Hauss4, T. Bernklev2,5, O. Høie6, M. Bjørn1,2
1Oslo University Hospital, Department of Gastroenterology, Oslo, Norway, 2University of Oslo, Faculty of Medicine, Oslo, Norway, 3Akershus University Hospital, Department of Gastroenterology, Oslo, Norway, 4Telemark Hospital Trust, Department of Gastroenterology, Skien, Norway, 5Vestfold Hospital Trust, Department of Research and Innovation, Tønsberg, Norway, 6Sørlandet Hospital Trust, Department of Gastroenterology, Arendal, Norway
Use of complementary and alternative medicine (CAM) is common among inﬂammatory bowel disease (IBD) patients.1 The CAM modalities used include a wide range of healthcare practices and therapies.2 The aim of this study was to examine possible associations between CAM use, clinical, and psychological factors, including health-related quality of life (HRQOL), 20 years after diagnosis.
The Inflammatory Bowel South-Eastern Norway (IBSEN) study is a population-based study with a prospective design. From January 1990 to December 1993, all newly diagnosed patients with IBD from a well-defined area in South Eastern Norway were included in the cohort. The 20-year follow-up was conducted between 2011 and 2014 and included a structured interview, a review of patient records, a clinical examination, laboratory tests, and patient-reported questionnaires. To measure chronic fatigue, HRQOL, anxiety and depression, we used the Fatigue Questionnaire, the Short - Form 36 (SF-36) and the Hospital Anxiety and Depression Scale (HADS), respectively. Additionally, patients answered a questionnaire about CAM use.
Of the 599 patients invited to the 20-year follow - up visit, 78.5% (UC 314, CD 156) participated. Altogether, 439 of the patients had evaluable questionnaires (response rate 93%), and of these 49% were men. In total 28% (122/439) reported the use of CAM for their IBD. Women were more likely to report CAM use than men (60% vs. 40%,
One third of the IBD patients reported CAM use 20 years after diagnosis. CAM use was associated with female gender, younger age, disease activity, chronic fatigue and lower HRQoL scores in 3 out of 8 dimensions.
1. Opheim R, Bernklev T, Fagermoen MS,
2. Langhorst J, Wulfert H, Lauche R,