P297 The change of bone mineral density in patients with inflammatory bowel disease
W. Moon*1, S. J. Park1, M. I. Park1, S. E. Kim1, J. H. Kim1, K. Jung1
1Department of Internal Medicine, Kosin University College of Medicine, Busan, South Korea
There is limited data regarding the impact of treatment for IBD on the BMD status. Therefore, this study aimed to identify the change of BMD in the patients with IBD after treatment including 5-aminosalicylic acid, thiopurine, and anti-TNF agents.
The cases were retrieved from 442 patients who were diagnosed with IBD in a single university hospital. Of those, 119 patients (CD 84, UC 35) had the follow-up BMD with at least 1-year interval. The associations between BMD, BMI and disease activity parameters including CDAI, Mayo-score, haemoglobin (Hb), c-reactive protein(CRP), serum albumin were evaluated as Pearson correlation analysis and partial correlation; BMD was measured as Z- score and low BMD was defined as less than −1.
In enrolled 84 patients with inactive CD, the baseline mean of BMD Z score at the lumbar spine and femur neck were −0.44 ± 1.36, −0.13 ± 1.28; the follow-up mean of BMD Z score at the lumbar spine and femur neck were −0.47 ± 1.21 (
There is no correlation with improvement of disease and BMD status after treatment in patients with IBD. However, in low BMD group of CD, treatment itself could improve the status of BMD of femur neck.