P322 Disease-related worries and concerns in patients with ulcerative colitis: 1-year data from ICONIC
S. Ghosh*1, F. Casellas2, C. O’Shea3, K. Kligys4, J. Petersson4, L. Peyrin-Biroulet5
1University of Birmingham, Birmingham, UK, 2Crohn-Colitis Care Unit (UACC), Hospital Universitari Vall, Vall d'Hebron, Spain, 3AbbVie Ltd., Dublin, Ireland, 4AbbVie Inc., North Chicago, Illinois, USA, 5University of Lorraine, Nancy, France
ICONIC is the largest ongoing, prospective, multi-country observational study assessing cumulative disease-associated burden in adults with ulcerative colitis (UC) under routine care. This analysis evaluated patient worries and concerns up to 1 year using the Rating Form of inflammatory bowel disease (IBD) Patient Concerns (RFIPC) questionnaire.
Adults with early UC (diagnosed ≤36 months) were enrolled irrespective of treatment regimen or disease severity. Patients completed RFIPC, a 25-item questionnaire comprising frequently reported worries/concerns of IBD patients, at each visit (6-month intervals). Responses are scored on a 10-cm visual analogue scale for each individual question from 0 (no concerns) to 10 (a great deal). The mean of all 25 items represents the total score (lower scores indicate less worries/concerns). In this analysis, data are reported as observed using descriptive statistics at baseline (visit 1 [V1]), month 6 (V2), and month 12 (V3). Patients were stratified by physician-assessed disease severity (mild, moderate, severe, or in remission) at baseline, gender, and geographic location.
Mean ± SD total RFIPC scores for all patients were 3.4 ± 2.2 (
Data from ICONIC demonstrated that patients with early UC are highly concerned with the treatment and complications of their disease at all severities of disease, with higher impact among patients with more severe disease. However, these worries decrease over time. Regional and gender differences in UC-related worries/concerns were observed.