P369 The comparative frequency of clostridial infection in patients with ulcerative colitis receiving mesenchymal stromal cells and anti-cytokine therapy
O. Knyazev1, A. Kagramanova*1, M. Chernova2, I. Korneeva1, D. Kulakov1, A. Parfenov1
1Moscow Clinical Scientific Center named after A. S. Loginov, Department of inflammatory bowel diseases, Moscow, Russian Federation, 2Moscow Clinical Scientific Center named after A. S. Loginov, Infection department, Moscow, Russian Federation
Patients with inflammatory bowel disease (IBD) experienced more frequent development of Clostridial infection and much higher rates of morbidity and mortality compared with patients without IBD. Risk factors are immunosuppressive therapy.
The aim is to compare the frequency of Clostridial infection (CI) in patients with ulcerative colitis (UC) receiving bone marrow mesenchymal stromal cells (MSC) and biological therapy.
The patients were divided into three groups: the first group (
In patients of the 1-st group, toxin A was detected in 1/23 patients (4.3%), in the 2-nd group - in 2/21 (9.5%) (RR - 0.45, 95% CI 0.04-4.6,
The frequency of Clostridial infection in patients with ulcerative colitis receiving mesenchymal stromal cells is significantly lower than in patients with ulcerative colitis receiving biological immunosuppressive preparations.