P433 Aetiologies of iron deficiency-related anaemia in German patients with inflammatory bowel disease
A. Aksan*1,2, E. Leventi1,3, K. Farrag1,3, I. Mavrommataki1,3, A. Dignass4, J. Stein1,3
1Interdisciplinary Crohn Colitis Centre Rhein-Main, Frankfurt/Main, Germany, 2Hacettepe University, Ankara, Turkey, 3DGD Clinics Sachsenhausen, Frankfurt/Main, Germany, 4Agaplesion Markuskrankenhaus, Frankfurt/Main, Germany
Iron deficiency (ID) is a common manifestation of IBD but frequently overlooked, even if anaemia is present. Causes of anaemia in IBD include intestinal bleeding, reduced iron intake, and impaired iron absorption due to acute inflammation. Thus, anaemia in patients with IBD is most commonly iron deficiency anaemia (IDA), anaemia of chronic inflammation (ACI), or a combination of both aetiologies (MIX). Anaemia can seriously impact quality of life, morbidity and hospitalisation rates and therefore requires prompt diagnosis and treatment with intravenous (IV) or oral iron preparations, depending on its severity and causes. We aimed to determine and compare the prevalence of different types of anaemia in patients with ulcerative colitis (UC) and Crohn's disease (CD).
Baseline data from IBD patients (
In total, 192 (71/37% male, 121/63% female) patients were enrolled, 55.2% (106/192) with CD and 44.8% (86/192) UC. Mean age was 37.9 ± 13.5 years; mean Hb was 9.4 ± 1.9 g/dl (CD, 9.3 ± 1.8 g/dl; UC, 9.5 ± 1.9 g/dl;
Iron deficiency anaemia was found to be the predominant aetiology of anaemia in patients with both UC and CD, with a slightly higher relative prevalence in UC. Patients with CD tended to have a higher probability of ACI, either alone or in combination with IDA. Besides effective iron therapy, inflammation management is therefore an important prerequisite for effective anaemia therapy in patients with IBD and iron-related anaemia.