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P455 Evaluation of the optic nerve function in patients with ulcerative colitis and Crohn’s disease

A. Skamnelos*1, A. Kavvadias1, P. Zafeiropoulos2, K. Katsanos1, I. Asproudis2, D. Christodoulou1

1University Hospital of Ioannina, Division of Gastroenterology, Ioannnina, Greece, 2University Hospital of Ioannina, Universital Eye Clinic, Ioannnina, Greece

Background

The purpose of our study was the evaluation of optic nerve function using conventional visual evoked potentials (cVEP) and multi-focal visual evoked potentials (mfVEP) in patients with ulcerative colitis and Crohn’s disease without known ophthalmological disease.

Methods

Twenty-six patients with ulcerative colitis and Crohn’s disease under treatment with anti-TNFa agent and normal visual acuity, and 36 healthy controls were examined with cVEP and mfVEP in both eyes. The potential and latency of P100 wave of cVEP and the maximum potential density and latency of the three most central rings of mfVEP and also their total values were studied by specialised ophthalmologists.

Results

As for the right eyes (OD) of the patients, there was no statistically significant difference for cVEP, in comparison with controls. As for mfVEP, there was a statistically significant difference between patients and controls to the mean value of potential density in ring 1 (p = 0.019, with mean value 228.77 ± 138,67 nV/deg2) and ring 3 (p = 0.016, with mean value 12.08 ± 8.50 nV/deg2) and to latency in ring 3 (p = 0.017, with mean value 180.80 ± 58.63 ms). Also a statistically significant difference was found in the total potential value (p = 0.021, with a value of 140.88 μV).

As for the left eye (OS), there were no statistically significant differences in cVEP between patients and controls. In the mfVEP, a statistically significant difference between patients and controls was revealed in the latency (p = 0.038, with latency mean value 166.07 ± 38.41 ms). Potential density in ring 2 was very close to in the statistical significance (p = 0.053).

Conclusion

The mfVEP method revealed disturbances in optic nerve function, in patients with Crohn’s disease or ulcerative colitis under biologic treatment without obvious ophthalmologic problems. These functional disorders are likely to be related to the disease and its treatment, so further research on the subject is warranted taking into account disease course.