P472 Efficacy of intravenous ustekinumab re-induction in patients with Crohn’s disease with a loss of response
V. Heron*1,2, N. Panaccione3, K. Candido1, T. Bessissow1, A. Bitton1, C. Seow3, R. Panaccione3, W. Afif1
1McGill University Health Centre, Department of Gastroenterology, Montreal, Canada, 2Mayo Clinic, Division of Gastroenterology and Hepatology, Rochester, USA, 3University of Calgary, Division of Gastroenterology and Hepatology, Calgary, Canada
Ustekinumab (UST) has been shown to be effective in inducing and maintaining remission in patients with Crohn’s disease (CD). However, a significant number of patients do not respond or experience a secondary loss of response (LOR). We assessed the utility of UST intravenous (IV) re-induction (~6 mg/kg) to achieve clinical and endoscopic response or remission in patients with active CD on UST maintenance therapy.
A multi-centre retrospective cohort study was performed. Adult patients (>18 years old) who received an IV re-induction dose of UST for either partial response or secondary LOR to UST, based on clinical, biochemical or endoscopic criteria, were identified at two Canadian academic centres. Post-reinduction, clinical remission was defined as an HBI < 5 off corticosteroids. Biochemical response and remission were defined as ≥ 50% decrease and normalisation, respectively, of faecal calprotectin (FCP) and/or CRP. Endoscopic remission was defined as a SES-CD score of < 3 and endoscopic response was defined as a decrease in SES-CD ≥ 50%. Adequate drug concentrations were defined as a UST level of ≥ 1 μg/ml. The primary outcome of interest was complete clinical, biochemical and endoscopic remission. Secondary outcomes included clinical remission, biomarker response, and safety.
Twenty-eight patients (median age 35.5 years, 46% women) underwent IV reinduction between January 2017 and July 2018. The indication for re-induction was partial response in 43% (
Ustekinumab IV reinduction can be used safely to induce complete remission and response in patients with Crohn’s disease with partial response or losing response, even in the context of previously defined adequate UST drug concentrations. Further studies evaluating this strategy are warranted.