P488 Perianal Crohn's disease in the biological era
F. Pires*1, A. Carvalho1, D. Martins1, E. Cancela1, A. Silva1, P. Ministro1
1Centro Hospitalar Tondela Viseu, Gastrenterologia, Viseu, Portugal
The purpose of this study was to characterise perianal disease (PD) in a cohort of patients with Crohn's disease (CD) followed prospectively for 10 years.
We performed a prospective cohort study to analyse data from 298 patients, 96 of whom with PD, over the period of 10 years (2007–2017). The characteristics of patients with PD were compared with controls with CD without PD. Perianal lesions were described in abscess, fistula, abscess and/or fistula, fissure, ulcer, fissure and/or ulcer, and stenosis. The Montreal classification was used to characterise CD.
The analysis of patients with and without PD showed no difference in sex, behaviour (B1, B2, B3) and involvement of the upper gastrointestinal tract (L4). However, the group of patients with PD had a significantly lower age at onset of symptoms (median=25.5 years, IQR 20.5–34.0) vs. patients without PD (median=30.5 years, IQR 22.0–41.0) (
One third of patients with CD had PD, which is more prevalent in patients with colic involvement. The severity of the perianal location can be inferred by the higher rate of abdominal surgery in this group of patients. Of the perianal lesions, abscess and/or fistula were associated with a worse overall prognosis. These data are in agreement with what is previously described in the literature. Patients with PD had higher rates of biological therapy, with a higher rate in patients with fistula compared with other lesions.