P548 Vedolizumab clinical decision support tool predicts hospitalisation, surgery, and healthcare resource utilisation
P. S. Dulai*1, Z. Huang2, Y. Wan2, M. Luo2
1University of California San Diego, La Jolla, CA, USA, 2Takeda Pharmaceuticals U.S.A., Inc., Deerfield, IL, USA
A clinical decision support tool (CDST) has been developed and validated to predict clinical and endoscopic remission with vedolizumab (VDZ) in Crohn’s disease (CD).1 We assessed whether this CDST could be applied in real-world settings using retrospective claims database to predict differences in CD-related hospitalisation, surgery, and other healthcare resource utilisation.
The Truven MarketScan Database was used to identify CD patients treated with VDZ after 1 May 2014. Patients were stratified into low or high probability of VDZ response based on the previously validated CDST. Rates of CD-related hospitalisation and surgery, rates of other healthcare resource utilisation, and related costs (hospitalisation, surgery, emergency department (ED) visit, office visit, endoscopy, imaging, and laboratory tests) were compared between the low and high probability of VDZ response groups for the 12 months after VDZ initiation.
A total of 1445 CD patients (
The VDZ CD CDST can stratify probability of CD-related hospitalisation and surgery, and we observed a significant difference in non-drug–related healthcare cost between the high and low probability of VDZ response groups. Further studies are needed to assess whether up-front stratification of CD patients with this tool could optimise the cost-effectiveness of VDZ utilisation.
1. Dulai PS, Boland BS, Singh S,