P549 Vitamin D deficiency as a part of extraintestinal manifestations in IBD Patients: a single-centre experience
A. Georgieva*1, A. Atanassova1, D. Gerova2, M. Todorova2
1Medical University Varna, Clinic of Hepatogastroenterology, St. Marina University Hospital, Vаrna, Bulgaria, 2Medical University Varna, Department of General Medicine and Clinical Laboratory, Varna, Bulgaria
Vitamin D deficiency is more common in inflammatory bowel disease (IBD) patients than it is in the general population. The aim of this study was to evaluate the vitamin D serum levels in IBD patients as a part of the extraintestinal manifestations (EIMs) and to correlate the prevalence of hypovitaminosis D with existence of other EIMs.
The Vitamin D (25 OH D) status was measured in 94 IBD patients, 54 with CD and 40 with UC. 25(OH) D serum concentrations were measured by a commercial paramagnetic particle chemiluminescent immunoassay for the quantitative determination of total 25-hydroxyvitamin D [25(OH) vitamin D] levels. Vitamin D deficiency is defined as a serum level of 25OHD <50 nmol/l, and a serum level ˃50 nmol/l <75 nmol/l is classified as vitamin D insufficiency. The clinical course and the occurrence of EIMs were monitored. All Patients were classified according to the Montreal classification. CD activity was assessed using the BEST index (CDAI - Crohn Disease Activity Index) and the partial Mayo score was used to determine UC activity.
Across all patients the mean serum 25(OH) D level was 44.47 ± 18.14 (nmol/l). Almost 95% of IBD patients have Vitamin D insufficiency and deficiency, respectively CD- 96.29% (
Over 96% of patients with the EIMs also have a low Vitamin D serum levels. This correlation leads to the need for systematic monitoring of 25-hydroxyvitamin D levels during the course, follow-up and treatment of IBD