P692 Positive histological margins is a risk factor of recurrence after ileocaecal resection in Crohn’s disease
C. Riault*1, M. Diouf2, D. Chatelain2, J. p. Le Mouel1, J. Loreau1, J. Turpin1, C. Yzet1, F. Brazier1, C. Sabbagh2, J. l. Dupas1, E. Nguyen-Khac1, M. Fumery1
1Amiens University Hospital, Gastro-enterology, Amiens, France, 2Amiens University Hospital, Amiens, France
Surgical resection is not curative in Crohn’s disease (CD) and recurrence after surgery is a common situation. The identification of patients at high risk of recurrence remains disappointing in clinical practice. The impact of residual microscopic disease on margins on the risk of recurrence after ileocaecal resection is still subject to debate.
All patients who underwent ileocaecal resection between January 1982 and December 2016 were prospectively identified. Demographic data, clinical, surgical and histological variables were retrospectively collected. Positive histological margin was defined by the presence of acute inflammatory lesions on margins: erosion, ulceration, chorion infiltration by neutrophils poly- nuclears, cryptic abscesses or cryptitis.
125 patients were included, with a median follow-up of 8 years (Interquartile Range (IQR), 4.3–15.2). Half (49.6%,
Positive histological margin, as defined by the presence of erosion, ulceration, chorion infiltration by neutrophils polynuclears, cryptic abscesses or cryptitis, was associated with an increased risk of clinical and surgical recurrence after ileocaecal resection for Crohn’s disease.