P729 Faecal calprotectin and faecal immunochemical test have different values depending on mucosal status in patients with ulcerative colitis
H. W. Kim*1, S. B. Park1, C. W. Choi1, D. H. Kang1, D. G. Ryu1
1Pusan National University Yangsan Hospital, Internal medicine, Yangsan, South Korea
Although faecal calprotectin (Fcal) and faecal immunochemical test (FIT) have been to be associated with endoscopic disease activity in ulcerative colitis (UC), the values of each marker depending on the mucosal status are not well known. This study evaluated the differences between two faecal markers depending on the mucosal status in UC.
A total of 174 results, obtained in simultaneous examination with endoscopy and faecal tests, were retrospectively evaluated for 127 UC patients from March 2015 to February 2018. The usefulness of faecal markers as a surrogate marker of endoscopic disease activity and the difference between faecal markers depending on the mucosal status was statistically evaluated. Endoscopic disease activity of UC was analysed by Mayo endoscopic subscore (MES) and ulcerative colitis endoscopic index of severity (UCEIS).
Both faecal markers showed statistically significant correlation with MES (r = 0.678 for Fcal (
Both Fcal and FIT were well correlated with endoscopic disease activity in UC patients. Fcal was more accurate correlation with endoscopic disease activity in patients with active inflammation, while FIT was more sensitive in predicting the achievement of complete mucosal healing.