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P729 Faecal calprotectin and faecal immunochemical test have different values depending on mucosal status in patients with ulcerative colitis

H. W. Kim*1, S. B. Park1, C. W. Choi1, D. H. Kang1, D. G. Ryu1

1Pusan National University Yangsan Hospital, Internal medicine, Yangsan, South Korea

Background

Although faecal calprotectin (Fcal) and faecal immunochemical test (FIT) have been to be associated with endoscopic disease activity in ulcerative colitis (UC), the values of each marker depending on the mucosal status are not well known. This study evaluated the differences between two faecal markers depending on the mucosal status in UC.

Methods

A total of 174 results, obtained in simultaneous examination with endoscopy and faecal tests, were retrospectively evaluated for 127 UC patients from March 2015 to February 2018. The usefulness of faecal markers as a surrogate marker of endoscopic disease activity and the difference between faecal markers depending on the mucosal status was statistically evaluated. Endoscopic disease activity of UC was analysed by Mayo endoscopic subscore (MES) and ulcerative colitis endoscopic index of severity (UCEIS).

Results

Both faecal markers showed statistically significant correlation with MES (r = 0.678 for Fcal (p < 0.001) and r = 0.635 for FIT (p < 0.001)) and UCEIS (r = 0.711 for Fcal (p < 0.001) and r = 0.657 for FIT (p < 0.001)). Fcal was significantly superior to FIT in predictive accuracy for endoscopic disease activity (AUC; 0.863 vs. 0.765 in MES (p < 0.001) and AUC; 0.847 vs. 0.757 in UCEIS (p < 0.001). FIT was significantly superior to Fcal in sensitivity for complete mucosal healing (98.0% vs. 78.4% in MES, 94.9% vs. 74.6% in UCEIS).

Conclusion

Both Fcal and FIT were well correlated with endoscopic disease activity in UC patients. Fcal was more accurate correlation with endoscopic disease activity in patients with active inflammation, while FIT was more sensitive in predicting the achievement of complete mucosal healing.