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P736 Characteristics of polymeric formula and mode of delivery of exclusive enteral nutrition have no effect on disease outcome and weight gain in children with Crohn’s disease

I. Hojsak*1, I. Trivic1, S. Sila1, K. Matic2, Z. Misak1, S. Kolacek1

1Children's Hospital Zagreb, Zagreb, Croatia, 2University of Zagreb, School of medicine, Zagreb, Croatia


This study aimed to evaluate the difference in the mode of exclusive enteral nutrition (EEN) delivery (orally or via nasogastric (NG) tube) and type of polymeric formula (with taste vs. tasteless and isocaloric vs. hypercaloric) on the disease outcome and nutritional status in children with Crohn’s disease (CD).


This was a single-centre retrospective study which included all CD patients which were initially treated with EEN in the period from October 2007 to November 2017. All patients received polymeric formula which was based on physicians and child preference provided orally or via NG tube.


A total of 92 CD patients were included in the study (mean age 13.6 ± 3.0 years; 45.7% female). Overall 42 (45.7%) patients received EEN via NG tube until the end of EEN period. Remission was achieved in 71 (77.2%) children. There was no difference in the EEN failure, remission duration, inflammatory markers and weight gain at the end of EEN period between oral intake and NG tube groups.

Oral (n = 50)NG tube (n = 42)p
EEN failure (n, %)12 (24)9 (21.4)0.808
Weight change after EEN (kg, mean ± SD)0.1 ± 2.80.4 ± 2.80.252
CRP change after EEN (mg/l, mean ± SD)−21.6 ± 5.8−36.3 ± 6.80.1

Difference between patients treated with exclusive enteral nutrition (EEN) and corticosteroids at diagnosis

None of the factors including age, type of formula (with taste vs. tasteless and isocaloric vs. hypercaloric) and mode of delivery (orally vs. trough NG tube for the whole duration of EEN) were associated with EEN failure.

HR95% CI
Enteral formula with taste0.4120.086–1.960
Hypercaloric (1.5 kcal/ml) enteral formula2.50.377–16.588
NG tube for the duration of EEN1.0010.286–3.504
Energy intake via EEN (kcal/kg body weight)0.9640.907–1.025

Risk factors at diagnosis associated with exclusive enteral nutrition (EEN) failure.


This study failed to demonstrate any benefit in the provision of EEN via NG tube in paediatric patients with CD.