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P754 Ovarian reserve in reproductive age women with Crohn’s disease

X. Peng*1, M. Zhi1, X. Gao1, P. Hu1

1The sixth hospital affiliated to sun yat-sen university, Gastroenterology dept., Guangzhou, China

Background

Crohn's disease incidence is rising year by year, and the young patients with high-risk. So more and more people begin to pay close attention to fertility, pregnancy, drug safety, lactation, etc. Although there are some studies have shown that crohn's disease is associated with fertility, but they were based on number of pregnancy, first pregnancy. No study penetrates the systemic research of ovarian function.

Methods

This clinical study recruit 45 childbearing age (17–40) patients with Crohn's disease and 45 matching age healthy women in the sixth hospital affiliated to sun yat-sen university during May 2017 to December 2017. Collect patients' demographic, menstruation, birth, serological indexes, CDAI, pathological changes, biological characteristics, medical history, surgical history data. And testing oestrogen (oestrogen, E2), follicle stimulating FSH (follicle stimulating hormone, FSH), Anti Mullerian tube hormone (anti-Mullerian hormone, AMH), sinus follicle count (antral follicle count, AFC) on third menstrual period.

Results

The two group had no difference between age and height. But the weight and BMI were significantly lower in CD patients than healthy group. The AMH and AFC were significantly lower in CD patients than healthy group (2.28 ± 2.09 ng/ml vs. 4.68 ± 2.12 ng/ml, 12 ± 6 vs. 16 ± 5,p < 0.05). Although the E2 were lower and the FSH were higher in CD patients, but there were no statistical differences. AMH were lower in patients with hypoproteinaemia than the patients with normal albumin levels (1.15 ± 1.19 ng/ml vs. 2.99 ± 2.14 ng/ml, p < 0.05). The patients treat with thalidomide had lower AMH than the patients with other drugs(1.09 ± 1.42 ng/ml vs. 2.64 ± 2.77 ng/ml,p < 0.05), but there were no relationship between AMH and lesion site, surgery.

Conclusion

The ovarian reserve function was significantly lower in childbearing age women with Crohn’s disease than heathy people, especially in patients with hypoalbuminaemia and treated with thalidomide.