Search in the Abstract Database

Abstracts Search 2019

P796 Cardiovascular risk profile in Greek patients with inflammatory bowel disease

E. Tsoukali*1, A. Mantaka2, E. Orfanoudaki2, N. Viazis1, C. Pitsavos3, D. Panagiotakos4, G. Mantzaris1, I. Koutroubakis2

1Evangelismos General Hospital of Athens, Gastroenterology Department, Athens, Greece, 2University Hospital of Heraklion, Gastroenterology Department, Heraklion, Greece, 3First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece, 4School of Health Science and Education, Harokopio University, Athens, Greece

Background

Inflammatory bowel diseases (IBD) are linked with a higher risk for cardiovascular diseases (CVD) due to the contribution of chronic systemic inflammation in the pathogenesis of atherosclerosis. However, the separate role of the traditional and non-traditional cardiovascular risk factors in this setting remains unclear. We aimed to investigate the prevalence of risk factors for cardiovascular diseases in Greek IBD patients in comparison to healthy controls.

Methods

Eligible were consecutive IBD patients aged 30–80 years without a prior CVD history followed in two tertiary referral centres. The cardiovascular risk profile was assessed by traditional risk factors [body composition measures (BMI), blood pressure, smoking status, plasma lipids and glucose] and non-traditional risk factors (inflammatory biomarkers) at a random point of time and compared with age-sex matched healthy controls from the ATTICA study. For the comparisons of proportions chi-square tests were used. Student's t-test and Mann–Whitney tests were used for the comparison of continuous variables between IBD patients and controls.

Results

Overall, 375 IBD patients [213 male, (199 CD, 176 UC), mean age 50.2 ± 12.8 years, mean age at IBD diagnosis 37.3 ± 13.6 years, 18.9% with a prior IBD-related surgery] were included and matched for age and sex with 750 healthy subjects from the ATTICA study. The proportion of obese subjects (BMI>30) was significantly higher in patients with IBD (19.6% vs. 1.9%, p < 0.001), whereas lower rates of hypertension were found in IBD patients (19.2% vs. 30.2%, p < 0.001) compared with healthy controls. Ever smokers were more in the IBD group (67.1% vs. 56.7%, p = 0.001), while the current smoker status was less common in the IBD group (31.9% vs. 41.5%, p = 0.002). Additionally, the rates of hypercholesterolemia were lower in those with IBD (12.5% vs. 43.7%, p < 0.001) whereas there was no statistical difference regarding the presence of diabetes (p = 0.187). Measurements at a random point of time showed significantly lower values of mean systolic and diastolic blood pressure, along with total cholesterol, low-density lipoprotein cholesterol and haemoglobin in IBD patients compared with healthy controls (all p < 0.05). Additionally, IBD patients had higher levels of high-density lipoprotein cholesterol, white blood cells, fibrinogen, platelets and C-reactive protein compared with controls (all p < 0.05).

Conclusion

Greek IBD patients have lower prevalence of traditional risk factors for CVD, except from obesity compared with healthy controls. Based on these results it could be suggested that systemic inflammation plays the most important role in the pathogenesis of CVD in IBD.