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P805 Fertility, conception and delivery in patients with IBD, a retrospective study in two centres in Greece

D. Moschovis*1, M. Velegraki2, A. Theodoropoulou2, E. Zacharopoulou1, I. Internos1, K. Stylianou3, M. Tzouvala1

1General Hospital of Nikea and Piraeus "Agios Panteleimon", Gastroenterology, Athens, Greece, 2General Hospital of Heraklion "Venizeleio", Gastroenterology, Heraklion, Greece, 3University General Hospital of Heraklion, Nephrology, Heraklion, Greece

Background

Patients with IBD are concern about fertility, conception and relapse of disease during pregnancy. Birth weight and pregnancy outcome seems to be related with surgical procedures and medical treatment.

Methods

We evaluated these parameters in a retrospective analysis of Greek IBD patients.

Results

In total 430 patients were registered, 212 men (49.3%) of median age 33 ± 14 and 218 women (50.7%) of median age 33.1 ± 14.5. The majority of them (54.9%) had Crohn’s disease (CD). No children have been reported by 173 (41.2%) patients: 99 males (46.7%) and 74 females (33.9%), p = 0.005. The rest 257 patients (59.8%) had at least one child (average 1.92 kids per patient). Patients with children are statistically older than these without (39 ± 13.8 vs. 24.3 ± 9.7, p < 0.001). Caesarean section was performed in 34% of deliveries (168/494). Median age of the first conception was 27.6 ± 6 years old in both sexes. For the women, median age of first, second and third conception was 25.7 ± 5.4, 27.7 ± 5 and 28.4 ± 7 year olds, respectively. One third of patient had their first child after the IBD diagnosis (n = 75, 29.2%), while 182 (70.8%) before.https://planner.smart-abstract.com/ecco2019/submission/en/abstract/13286/content#. Women with active disease at conception had clinical relapse during pregnancy more often than these with quiescent disease (37.5% vs. 4.8%, p = 0.005). Moreover, active disease in conception increased the risk of clinical relapse during pregnancy 12 times (ΟR = 12, 95% CI = 1.6–90). Relapse during pregnancy increased the risk of preterm delivery from 1.5% to 28.6% (p < 0.001). Infant’s weight was, as expected, statistically lower in preterm deliveries (p < 0.001) as well as in pregnancies with relapse of IBD (2934 vs. 3227.5 g, p = 0.16). Infant’s weight from parents with serious disease (surgery) was lower than these from parents without surgeries or parents that had children before IBD diagnosis (2754 ± 1089 vs. 3183.8 ± 521 vs. 3317 ± 571 g, respectively, p = 0.043). Additionally, infant’s weight from parents that conceived after IBD diagnosis was lower compared with the infants that were before IBD diagnosis (3076 ± 490 vs. 3293.5 ± 567 g, p = 0.017).

Conclusion

Fertility, conception, birth weight and outcome of pregnancies in Greek IBD patients do not differ from these published in other populations.