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P812 Anaemia during Crohn's disease: Does its mechanism predict the extent of the disease?

A. Sabbek*1, N. Elleuch2, M. Ksiaa2, E. Hammami2, H. Jaziri2, A. Braham2, S. Ajmi2, A. Ben Slama2, A. Jmaa2

1Sahloul Sousse, Gastroenterology, Sousse, Tunisia, 2Sahloul Sousse, Sousse, Tunisia

Background

Anaemia is the most common extraintestinal complication during Crohn's disease (CD). Several studies have looked at possible mechanisms and its treatment but few have tried to link it to a specific localisation of the disease. The aim of our study is to determine the prevalence, mechanisms of anaemia during CD and seek for a locational value by type.

Methods

A retrospective descriptive and analytical study, spread out over 5 years, including patients diagnosed with a CD at the department of gastroenterology of Sousse. Anaemia was defined as haemoglobin < 13 g/dl in men and < 12 g/dl in women.

Results

We collected 166 patients of mean age 42.9 years [15–73 years] and sex ratio 0.55. Two thirds of the patients were anaemic (75.3%) with an average haemoglobin level of 10.4 g / dl [6.7–11.8 g/dl]. Iron deficiency anaemia was found in 62.4% of cases (N = 78). Normocytosis was found in 37.6% of cases (N = 47). In this case, it was associated with inflammatory anaemia in 51.06% of cases (ferritin blood level average : 157 ng/ml [102–406 ng/ml]), an haematologic toxicity of azathioprine in 14.9% and combined vitamin B12 and iron deficiency anaemia in 34.04% of cases. A statistically significant correlation was found between iron deficiency anaemia and ileocolic localisation of the disease (p = 0.05). In addition, combined normocytic anaemia was more common in cases of extensive ileal localisation without significant correlation (p = 0.06). Inflammatory anaemia had no locating value.

Conclusion

In our study, anaemia was predominantly iron-deficient and was associated with ileocolic localisation, unlike inflammatory anaemia, which had no locating value. More large studies are needed to confirm our hypotheses.