P840 Dietary interventions rapidly alter metabolomics profile of patients with inflammatory bowel disease after pouch surgery
L. Godny*1,2, L. Reshef3, T. Pfeffer-Gik1,2, K. Rabinowitz1,2, I. Goren1,2, K. Yadgar1, K. Zonensain1, R. Barkan1, H. Yanai1,2, U. Gophna3, H. Tulchinsky4, I. Dotan1,2
1Rabin Medical Center, Division of Gastroenterology, Petah-Tikva, Israel, 2Tel Aviv University, Sackler Faculty of Medicine, Tel Aviv, Israel, 3Tel Aviv University, Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv, Israel, 4Tel Aviv Sourasky Medical Center, Proctology Unit, Department of Surgery, Tel Aviv, Israel
Diet may play a role in the pathophysiology of inflammatory bowel diseases (IBD) via several mechanisms including metabolome alteration. We conducted an interventional cross-over study aiming to evaluate the short-term effect of two dietary regimens, the Mediterranean diet (MED) and the specific carbohydrate diet (SCD) on multiple biomarkers of patients with IBD after pouch surgery.
Two short (one-week) dietary interventions (MED and SCD) were provided to patients. After one washout week, patients were crossed over between diets. Both diets excluded industrialised and processed food. Faecal samples were collected and analysed for metabolomics profiling.
Overall 28 patients (male gender: 50%, mean age: 49 ± 13 years, mean pouch age: 12 ± 9 years) were recruited. Of those, 15 had a normal pouch, 12 had pouchitis and 1 - familial adenomatous polyposis. All patients completed both investigated dietary regimens. MED and SCD were isocaloric (Kcal: 1910 ± 575 vs. 1857 ± 614,
In this cross-over trial, two unindustrialised dietary interventions (MED and SCD) rapidly altered the metabolomic profile of patients with IBD after pouch surgery, despite individual metabolomic signatures. Changes in these metabolites might alter signalling pathways associated with inflammatory responses via autophagy and activation of NLRP3 inflammasome. Thus, personalised dietary intervention may be used to modify inflammation in IBD via altering metabolomics profile.
- Posted in: Poster presentations: Microbiology (2019)