P859 Hepatitis E seroprevalence in Portuguese inflammatory bowel disease patients under immunosuppression is higher than expected
M. Garrido*1, T. Guedes1, M. Abreu2, I. Pedroto1, P. Lago1
1Centro Hospitalar Universitário do Porto, Gastroenterology, Porto, Portugal, 2Centro Hospitalar Universitário do Porto, Infectious Diseases, Porto, Portugal
Hepatitis E virus (HEV) infection has been recognised over the past decade as an emerging disease. Immunosuppressed patients can develop chronic HEV infection, with the level of immunosuppression determining the clinical course of infection. Inflammatory bowel disease (IBD) patients frequently receive immunosuppressant agents, but the risk of developing chronic HEV infection has not been extensively accessed in this group of patients. Seroprevalence in developed countries is variable with the reported prevalence in portuguese general population being 19.9%. The aim of this study was to determine HEV seroprevalence in patients with IBD undergoing immunosuppression.
We prospectively tested all consecutive IBD patients referred to the specific Infectious Diseases Prevention in Immunocompromised Patients outpatient clinic of our institution. Anti-HEV-IgG antibodies were detected in serum by commercial enzyme immunoassay (HEV Ab, DiaPro Diagnostic Bioprobes, Milan, Italy), following the manufacturer’s instructions. Level of immunosuppression was defined according to IDSA criteria. Disease activity was defined as a Harvey–Bradshaw Index Score ≥5 or a Total Partial Mayo Index Score ≥2.
A total of 62 patients were included (median age 48.8 years, IQR 39,2–58,6 years; 51.6% male), with a median disease time of 19 years (IQR 13–25 years). The majority were diagnosed with Crohn’s disease (
A higher than expected prevalence of anti-HEV antibodies positivity was detected in our institution immunosuppressed IBD patients and, although non-significant, anti-HEV positivity increased with higher levels of immunosuppression.