OP16 The first virtual chromoendoscopy artificial intelligence system to detect endoscopic and histologic remission in Ulcerative Colitis
Iacucci, M.(1);Cannatelli, R.(2);Parigi, T.L.(1,3);Buda, A.(4);Labarile, N.(5);Nardone, O.M.(6);Tontini, G.E.(7);Rimondi, A.(7);Bazarova, A.(8);Bhandari, P.(9);Bisschops, R.(10);De Hertogh, G.(10);Del Amor, R.(11);Ferraz, J.G.(12);Goetz, M.(13);Gui, X.(14);Hayee, B.(15);Kiesslich, R.(16);Lazarev, M.(17);Naranjo, V.(11);Panaccione, R.(12);Parra-Blanco, A.(18);Pastorelli, L.(19);Rath, T.(20);Røyset, E.S.(21);Vieth, M.(22);Villanacci, V.(23);Zardo, D.(24);Ghosh, S.(25);Grisan, E.(26,27);
(1)University of Birmingham, Immunology and Immunotherapy, Birmingham, United Kingdom;(2)ASST Fatebenefratelli Sacco, Department of Gastroenterology, Milan, Italy;(3)Humanitas Research Hospital, Department of Biomedical Sciences, Milano, Italy;(4)Ospedale di Feltre, Digestive Endoscopy, Feltre BL, Italy;(5)National Institue of Research "Saverio De Bellis", Section of Gastroenterology II, Castellana Grotte, Italy;(6)Federico II University, Department of Gastroenterology, Naples, Italy;(7)University of Milan, Department of Pathophysiology and Transplantation, Milan, Italy;(8)University of Cologne, Institute for Biological Physics, Cologne, Germany;(9)Queen Alexandra Hospital, Department of Gastroenterology, Portsmouth, United Kingdom;(10)University Hospitals Leuven, Department of Gastroenterology, Leuven, Belgium;(11)Universitat Politécnica de Valéncia, Instituto de Investigación e Innovación en Bioingeniería- I3B, Valencia, Spain;(12)University of Calgary Cumming School of Medicine, Department of Gastroenterology, Calgary, Canada;(13)Klinikum Böblingen, Division of Gastroenterology, Böblingen, Germany;(14)University of Washington School of Medicine, Department of Laboratory Medicine and Pathology, Seattle, United States;(15)King’s College Hospital, King’s Health Partners Institute of Therapeutic Endoscopy, London, United Kingdom;(16)Helios HSK Wiesbaden, Department of Gastroenterology, Wiesbaden, Germany;(17)John Hopkins Hospital, Department of Gastroenterology, Baltimore, United States;(18)University of Nottingham, Department of Gastroenterology, Nottingham, United Kingdom;(19)IRCCS Policlinico San Donato, Department of Gastroenterology, Milan, Italy;(20)University of Erlangen, Department of Gastroenterology, Nuremberg, Germany;(21)Norwegian University of Science and Technology, Department of Clinical and Molecular Medicine, Trondheim, Norway;(22)Klinikum Bayreuth- Friedrich-Alexander University, Institute of Pathology, Erlangen-Nuremberg, Germany;(23)ASST Spedali Civili, Institute of Pathology, Brescia, Italy;(24)University Hospitals Birmingham NHS Trust, Department of Cellular Pathology, Birmingham, United Kingdom;(25)University of Cork, School of Medicine, Cork, Ireland;(26)London South Bank University- London- UK, School of Engineering, London, United Kingdom;(27)University of Padova, Department of Information Engineering, Padova, Italy;
Endoscopic and histologic activity are important therapeutic targets in ulcerative colitis (UC). The Paddington International Virtual ChromoendoScopy ScOre (VCE-PICaSSO)1 demonstrated that enhanced visualisation of subtle mucosal and vascular inflammatory changes correlated strongly with histology. However, without adequate training, the subjective evaluation of white light (WL) and VCE endoscopic scores varies between observers. We aimed to develop an artificial intelligence (AI) system for objective assessment of endoscopic disease activity and predict histology related to both white light and VCE videos.
469 endoscopy videos (48512 frames) from 235 patients representative of all grades of inflammation, from our prospective PICaSSO multicentre study1 were used to develop a convolutional neural network (CNN). 316 videos were divided into training (254) and validation (62) sets. 153 additional videos (78 patients) were used as test cohort. The videos were edited to separate clips with WL and with VCE, and assessed using Ulcerative Colitis Endoscopic Index of Severity (UCEIS) and PICaSSO, respectively. The classification stage of a pre-trained ResNet50 CNN classifier was trained to predict the healing or active inflammation on video frames. One network was trained to predict endoscopic remission (ER) as UCEIS≤1 from WL frames, and a second network was trained to predict PICaSSO≤3 from VCE. Histological remission (HR) was defined as Robarts Histological Index (RHI) ≤3 with no neutrophils in lamina propria or epithelium.
In the validation cohort, our system predicted ER (UCEIS ≤1) in WL videos with 82% sensitivity (Se), 94% specificity (Sp) and an area under the ROC curve (AUROC) of 0.92. For the detection of remission in VCE videos (PICaSSO ≤3) Se was 74%, Sp 95%, and AUROC 0.95. In the testing cohort of independent videos, the diagnostic performance for both cut offs of ER remained similar. Table 1
Our system also had an excellent diagnostic performance for the prediction of HR in the validation set, with Se, Sp, and Accuracy of 92%, 83%, and 85% respectively, using VCE, and 83%, 87%, and 86% respectively, with WL. In the testing set performance declined modestly while remaining good. Of note, the algorithm’s prediction of histology was similar with VCE and WL videos. Table 2
Our AI system accurately recognize endoscopic remission in videos and predict histological remission equally well. This is the first AI model developed to analyse inflammation and endoscopic remission in VCE through the PICaSSO score, and the first multi-domain system providing a complete endoscopic and histologic assessment.
1. Iacucci et al. Gastroenterology 2021