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P119 There is minimal agreement on the recognition of deep ulcers as seen on endoscopy in patients with Inflammatory Bowel Disease: a national survey

Chavannes, M.(1);Hart, L.(2);Afif, W.(3);Lakatos, P.(3);Bitton, A.(3);Bressler, B.(4);Bessissow, T.(3);

(1)Children's Hospital Los Angeles- University of Southern California, Department of Pediatrics- Division of Gastroenterology- Hepatology and Nutrition, Los Angeles, United States;(2)Montreal Children’s Hospital, Division of Pediatric Gastroenterology- Hepatology and Nutrition, Montreal, Canada;(3)McGill University Health Centre, Division of Gastroenterology, Montreal, Canada;(4)University of British Columbia, Division of Gastroenterology- Department of Medicine, Vancouver, Canada

Background

Deep ulcers have been described as a marker of severe disease phenotype in patients with IBD and play a role in choice or escalation of therapy. However, there is no agreed upon characterization of deep ulcers in the literature. We therefore assessed Canadian gastroenterologists’ ability to identify the presence of deep ulcers on endoscopic images.

Methods

We present a post-hoc analysis of a cross-sectional questionnaire from gastroenterologists across Canada (March-October 2017). Three IBD experts independently rated 20 ileocolonoscopy images of single bowel segments. They described the images by selecting descriptors from a list developed a priori. Images described by all 3 experts as having “deep ulcers” were retained for analysis (5 images). Survey participants similarly applied descriptors from the same list to each endoscopy image. We examined the percent agreement between the gastroenterologists and the experts. The percent agreement for each question was summarized using median and IQR. Difference in median scores in physician subgroups was determined using the Mann-Whitney U test. We also assessed the inter-observer agreement on the presence of deep ulcers amongst gastroenterologists using Fleiss Kappa. 

Results

131 gastroenterologists participated in the study. The majority (55.7%) were between 36-50 years old. 48% were in practice for less than 10 years. 59.5% practiced in an academic setting. 9.9% of responders were pediatric gastroenterologists. The median agreement between the gastroenterologists and the experts was 30.5% (30.5-76.3), indicating an under-recognition of deep ulcers. As a group, inter-observer agreement on the presence of deep ulcers was minimal (k = 0.39, CI: 0.16-0.65). Inter-observer agreement was lower in the academic setting than the community setting (k= 0.39 vs k= 0.49 respectively) and was fairly similar in those with more experience compared to those with less experience (k= 0.40 for less than 10 years in practice, vs k= 0.36 for those with greater than 10 years in practice).  Compared to the experts’ responses, there was no significant difference if the physician practiced in an academic vs community setting (49.24% correct identification vs 54.52%, p = 0.6004) or if the physician had less than 10 years’ experience vs greater than 10 years’ experience (48.26% vs 53.44%, p =0.2948).

Conclusion

Deep ulcers have been described as a critical indicator of disease severity in patients with IBD. However, our study shows that there is poor agreement between physicians in identifying this important feature. This indicates the need for a standardized definition of deep ulcers to prevent undertreatment of patients who require escalated therapy.

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