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P136 Management of patients with Inflammatory Bowel Disease and their outcome during the first wave of Covid-19 pandemics.

Viola, A.(1);Giambò, F.(1);Chiappetta, M.F.(1);Costantino, G.(1);Pallio, S.(2);Navarra, G.(3);Alibrandi, A.(4);Fries, W.(1);

(1)University of Messina, IBD-unit- Dept. of Clinical and Experimental Medicine, Messina, Italy;(2)University of Messina, Endoscopy-unit- Dept. of Clinical and Experimental Medicine, Messina, Italy;(3)University of Messina, Department of Human Pathology in Adulthood and Childhood "G. Barresi", Messina, Italy;(4)University of Messina, Department of Economics- Unit of Statistical and Mathematical Sciences, Messina, Italy

Background

The restrictions adopted in Italy during the phase I COVID-19 pandemics with a nationwide lockdown period, represented a challenge in the management of Patients with Inflammatory Bowel Disease (IBD) patients. The aim of the present study was to assess if, and how, a limited course of telemedicine did influence the clinical outcome in patients with Crohn’s disease (CD) and Ulcerative Colitis (UC).

Methods

IBD patients followed before March 8th, 2020 were included and divided into 3 groups (Fig.1): group 1, patients on endovenous biologics (EV); group 2, patients on biologics administered subcutaneously (SC); and group 3, patients on conventional treatments (CT) at the start of lockdown. The primary outcome was to assess the occurrence of disease flare in the three groups since only the EV group received face-to-face visits during lockdown. As secondary outcome we assessed the number of control endoscopies performed and the start of new biologic therapies, compared with a reference period in 2019.Flow-chart of the study; e.v.=endovenous administration, s.c.=subcutaneous administration.

Results

A total of 689 patients (CD: 369, UC 320) were included in the study (247 IV, 217 SC and 225 CT, respectively). Telemedicine was more frequently adopted in SC and CS, (p<0.001) both. Treatment delays or transitory stops were more frequent in EV (p<0.001), whereas there was a significantly greater need to change therapy (p= 0.038) and need for steroids (p = 0.008) in the SC group compared with EV (Tab.1). Concerning endoscopies, compared with the reference period in 2019 only 25% of scheduled endoscopies were performed. The only risk factor for disease flare during or shortly after lockdown was belonging to the patient groups subjected to telemedicine (SC and CT groups) (p < 0.001).

    Biologics e.v. n=247 Biologics s.c. n=217 conventional therapy n=225 p value
Programmed visits in presence; n (%) 199 (81) 42 (19) 47 (21) <0.001
Stop or delay of therapy; n(%) 36 (6) 5 (2) 2 (0.8) <0.001
Unscheduled visits because of flare; n(%) 7 (3) 11 (5) 10 (4) 0.471
Steroid need; n(%) 11 (4) 28 (13) 26 (6) 0.008
Need to change therapy; n(%) 10(4) 23 (11) 19 (8) 0.038
Hospitalization; n(%) 1 (0.4) 4 (2) 1 (0.4) 0.302

Table 1: comparison of visits (face-to-face or telemedicine); treatment interruption or delay of scheduled treatments, unscheduled appointments because of flare, steroid need or need to change therapy, hospitalisations, and surgery between the three study groups; chi-square-test.

Conclusion

Patients followed with a face-to-face approach instead of telemedicine, had a lower risk of disease flare during lockdown period. The impact of the important reduction of endoscopic assessments still needs to be assessed.

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