P175 Fatty liver disease as a complication of immune-mediated inflammatory diseases: prevalence and risk factors in inflammatory bowel disease
M.T. Arias Loste1, M.J. García García1, J.C. Rodriguez-Duque1, P. Iruzubieta1, C. Rivas1, M. Pascual1, B. Castro1, A. García2, L. Lopez-Montejo1, L. Rasines1, E. Garcia-Nieto2, M.L. Cagigal3, M. Rivero1, J. Crespo1
1Marqués de Valdecilla University Hospital., Gastroenterology, Santander- Cantabria, Spain, 2Investigation Institute Marques de Valdecilla- IDIVAL, Infection- Immunity and Digestive Diseases Group, Santander- Cantabria, Spain, 3Marqués de Valdecilla University Hospital, Pathology, Santander- Cantabria, Spain
Previous publications made by our group showed an increased prevalence of fatty liver disease (NAFLD) in immune-mediated inflammatory diseases (IMIDs). However, the existing data on inflammatory bowel disease (IBD) are contradictory.
Hypothesis: the prevalence of NAFLD is increased in IBD independently of the presence of metabolic factors.
Cross-sectional case–control study. Cases: prospective cohort single-center IBD patients. Controls: random sample from general population (Ethon cohort) paired 1: 2 by age, sex, BMI and T2D diagnosis. The diagnosis of NAFLD has been established by transition elastography (TE) CAP and confirmed by liver biopsy.
The study scheme is presented in the figure. The prevalence of NAFLD is higher in IBD vs. general population (
The prevalence of NAFLD is higher in IBD patients, with IBD being an independent predictor of NAFLD. Patients with IBD and NAFLD have a higher systemic inflammatory burden and this results in an increased risk of advanced fibrosis associated with IBD comparatively with the control NAFLD population.