P203 FIT and FC as a surrogate non-invasive marker for mucosal healing in inflammatory bowel disease
M.S. ISMAIL, G. Murphy, C. Kelly, F. O’Riordan, S. Semenov, S. Sihag, N. Breslin, O. Anthony, B. Ryan, D. McNamara, Trinity Academic Gastroenterology Group Trinity College Dublin
Tallaght University Hospital, Gastroenterology, Dublin, Ireland
Mucosal healing (MH) is one of the goals of IBD therapy. Currently, the only way to assess MH is by colonoscopy. Faecal calprotectin (FC) and faecal immunochemical test (FIT) which detect colonic inflammation and bleeding might be useful adjuncts.
To assess FIT and FC as surrogate markers of MH.
Following ethical approval, patients undergoing routine colonoscopy were prospectively recruited. Demographics and colonoscopy findings were documented. A FIT and FC were collected prior to colonoscopy. FIT and FC were processed in our laboratory and reported as µg/g of stool. MH was defined no visible activity on colonoscopy.
Of 105 colonoscopies, FC and FIT results were available in 99 and 88 patients. Mean age 48.8, 52% (55) males, 34% (36) UC, 60% (63) Crohn’s, 0.05% (6) IBDU. In all, MH occurred in 12%, (
MH was uncommon (12%) reflecting our clinical practice. FIT was a poor predictor of MH. FC might be a useful marker albeit ongoing research is needed to set an appropriate cut-off.