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P247 Carotid Plaque Assessment reclassifies patients with Inflammatory Bowel Disease into Very-High Cardiovascular Risk

Hernandez Camba, A.(1);Carrillo-Palau, M.(2);Ramos, L.(2);Hernández Alvarez-Buylla, N.(2);Alonso-Abreu, I.(2);Hernández, A.(2);Vela, M.(1);Arranz, L.(1);Hernández-Guerra, M.(2);González-Gay, M.A.(3);Ferraz- Amaro, I.(4);

(1)Hospital Universitario de Nuestra Señora de la Candelaria, Gatroenterology, Santa Cruz de Tenerife, Spain;(2)Hospital Universitario de Canarias, Gastroenterology, La Laguna, Spain;(3)Hospital Universitario Marqués de Valdecilla, Rheumatology, Santander, Spain;(4)Hospital Universitario de Canarias, Rheumatology, La Laguna, Spain

Background

The addition of carotid ultrasound into cardiovascular (CV) risk scores has been found to be effective in identifying patients with chronic inflammatory diseases at high-CV risk. We aimed to determine if its use would facilitate the reclassification of patients with inflammatory bowel disease (IBD) into the very high-CV-risk category and whether this may be related to disease features.

Methods

Multicenter cross-sectional study encompassing 186 IBD patients and 175 controls. Systematic Coronary Risk Evaluation (SCORE), disease activity measurements, and the presence of carotid plaques by ultrasonography were assessed. Reclassification was compared between patients and controls. A multivariable regression analysis was performed to evaluate if the risk of reclassification could be explained by disease-related features and to assess the influence of traditional CV risk factors on this reclassification.

Results

After evaluation of carotid ultrasound, a significantly higher frequency of reclassification was found in patients with IBD compared to controls (35% vs. 24%, p=0.030). When this analysis was performed only on subjects included in the SCORE low-CV-risk category, 21% IBD patients compared to 11% controls (p = 0.034) were reclassified into the very high-CV-risk category. Disease related data, including disease activity, were not associated with reclassification after fully multivariable regression analysis. Traditional CV risk factors showed a similar influence over reclassification in patients and controls. However, LDL-cholesterol disclosed a higher effect in controls compared to patients (beta coef. 1.03[95%CI 1.02-1.04] vs. 1.01[95%CI 1.00-1.02], interaction p=0.035) after adjustment for confounders.

Conclusion

Carotid plaque assessment is useful to identify high-CV risk IBD patients.

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