P282 Early disease acceleration in patients with newly diagnosed Crohn’s disease in India and Israel: Insights from an East-West inception cohort
I. Goren1, H. Yanai1, P. Pal2, B. Adigopula2, S. Pendyala2, G. Ganesh2, K. Yadgar1, R. Banerjee2, I. Dotan1, The Indo-Israeli IBD GastroEnterology paRtnership, ‘TiiiGER’ project
1Rabin Medical Center, Division of Gastroenterology, Petah Tikva, Israel, 2Asian Institute of Gastroenterology, Gastroenterology, Hyderabad, India
Environmental and genetic factors might affect Crohn’s disease (CD) course. These are significantly different in developing countries such as India compared with the West, and may affect triggers of disease development and its early course. We aimed to assess early CD course in patients in India compared with Israeli patients (‘TiiiGER’ project).
Adults (>18 years) diagnosed with CD using accepted clinical, endoscopic and histologic criteria were prospectively recruited. Disease acceleration was defined by the first CD-related surgery, CD-related hospitalisation or recommendation to start steroids, immunomodulatory or biologic therapy.Overall 104- Indian and 156-Israeli patients were recruited. Indian patients had male predominance (65.4% vs. 50.6%,
In this Indo-Israeli inception cohort, more than half of the patients with newly diagnosed CD experienced early disease acceleration. Distinct features, different rates of disease acceleration and treatment policies, highlight the global need for research into key factors in IBD evolution across ethnically and geographically diverse populations.
*The final two authors contributed equally.