P485 Apolipoprotein C3 is Downregulated in Patients with Inflammatory Bowel Disease
Hernandez Camba, A.(1);Carrillo Palau, M.(2);Ramos, L.(2);Alonso, I.(2);Vela, M.(1);Hernández, A.(2);Arranz , L.(1);Hernández, N.(2);Hernández-Guerra, M.(2);Ferráz, I.(3);
(1)Hosp. Universitario Nuestra Señora de la Candelaria, Department of Gastroenterology, Santa Cruz de Tenerife, Spain;(2)Hospital Universitario de Canarias, Gastroenterology, La Laguna, Spain;(3)Hospital Universitario de Canarias, Reumatology, La Laguna, Spain; ATEROEII
Background
Inflammatory bowel disease (IBD) has been associated with an abnormal lipid profile. Apolipoprotein C3 (ApoC3) is a key molecule of triglycerides metabolism that is known to be related to inflammation and cardiovascular (CV) disease. In the present study, we aim to study if ApoC3 serum levels differ between patients with IBD and controls, and if the hypothetical disturbance of ApoC3 can be explained by IBD characteristics.
Methods
Cross-sectional study that included 405 individuals, 197 patients with IBD and 208 age- and sex-matched controls. ApoC3 and standard lipid profiles were assessed in patients and controls. A multivariable analysis was performed to analyze whether ApoC3 serum levels were altered in IBD and to study their relationship to IBD characteristics.
Results
After fully multivariable analysis including CV risk factors, use of statins, and changes in the lipid profile caused by the disease itself, patients with IBD showed significant lower serum levels of ApoC3 (beta coef. -1.6 [95%CI -2.5- -0.7] mg/dl, p=0.001). Despite this, inflammatory markers, disease phenotypes or disease activity of IBD were not found to be responsible for this downregulation.
Conclusion
Apolipoprotein C3 is downregulated in patients with IBD.