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P493 Cost-effectiveness of venous thromboembolism prophylaxis after hospitalization in patients with Inflammatory Bowel Disease

Lee, K.(1);Lim, F.(2);Colombel, J.F.(3);Hur, C.(2);Faye, A.(3);

(1)Columbia University Vagelos College of Physicians and Surgeons, Medicine- Division of Digestive and Liver Diseases, New York, United States;(2)Columbia University Irving Medical Center, Medicine- Division of Digestive and Liver Diseases, New York, United States;(3)Icahn School of Medicine at Mt. Sinai, The Dr. Henry D. Janowitz Division of Gastroenterology, New York, United States

Background

Patients with inflammatory bowel disease (IBD) have a 2- to 3-fold greater risk of venous thromboembolism (VTE) than the general population, with increased risk during hospitalization. However, recent evidence suggests that this increased risk persists post-discharge. As such, we aimed to determine the cost-effectiveness of post-discharge VTE prophylaxis among hospitalized patients with IBD.

Methods

A decision tree was used to compare inpatient prophylaxis alone versus 4 weeks of post-discharge VTE prophylaxis with rivaroxaban 10 mg/day. Our primary outcome was quality-adjusted life years (QALYs) over one year, and strategies were compared using a willingness to pay of $100,000/QALY from a societal perspective. Costs (in 2020 $US), incremental cost-effectiveness ratios (ICERs), and number needed to treat (NNT) to prevent one VTE and VTE death were calculated. Deterministic 1-way and probabilistic analyses were performed to assess uncertainty within the model.

Results

Four-week post-discharge prophylaxis with rivaroxaban resulted in 1.68 higher QALYs per 1000 persons and an incremental cost of $185,778 per QALY as compared to no post-discharge prophylaxis. The NNT to prevent a single VTE was 78 individuals, while the NNT to prevent a single VTE-related death was 3190 individuals. One-way sensitivity analyses showed that higher baseline VTE risk >4.5% or decreased cost of rivaroxaban ≤$280 can reduce the ICER to <$100,000/QALY. Probabilistic sensitivity analyses favored post-discharge prophylaxis in 26.5% of iterations.

Table. Cost-effectiveness analysis results

 Post-discharge VTE prophylaxisNo post-discharge VTE prophylaxis
Cost (in 2020 $US)$690.39$377.45
Incremental cost$312.94-
Effectiveness (QALYs)0.997730.99604
Incremental effectiveness1.68 QALYs per 1000 persons-
ICER$185,778/QALY-
NNT to prevent one VTE78-
NNT to prevent one VTE-related death3190-

Abbreviations: QALY (Quality-Adjusted Life Years), ICER (Incremental Cost-Effectiveness Ratio), NNT (Number Needed to Treat), VTE (Venous Thromboembolism)

Figure. Tornado diagram showing main drivers (variables and sensitivity ranges) of the incremental cost-effectiveness ratio (ICER).
Figure. Tornado diagram.
*Values represent threshold values that reduce the ICER to <$100,000/QALY.
Abbreviations: VTE (Venous Thromboembolism), DVT (Deep Vein Thrombosis), PE (Pulmonary Embolism), PTS (Post-Thrombotic Syndrome), WTP (Willingness To Pay), EV (Expected Value)

Conclusion

Four weeks of post-discharge VTE prophylaxis results in higher QALYs as compared to inpatient prophylaxis alone, and can prevent one post-discharge VTE among 78 patients with IBD. As such, post-discharge VTE prophylaxis in patients with IBD should be considered in a case-by-case scenario considering VTE risk profile, costs, and patient preference.

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