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P625 Characteristics of SARS-CoV-2 infection in IBD patients in the second and third wave compared with the first wave and with the data of general population

Guerra Marina, I.(1);Algaba, A.(1);Castro, S.(2);Jiménez, L.(1);Garza, D.(1);Aller, M.D.M.(1);Granja, A.(1);Guardiola, A.(1);Gil, M.(2);Ruiz, P.(2);Bermejo, F.(1);

(1)Hospital Universitario de Fuenlabrada and Instituto de Investigación Sanitaria Hospital Universitario La Paz IdiPAZ, Gastroenteorlogy, Madrid, Spain;(2)Hospital Universitario de Fuenlabrada, Gastroenteorlogy, Madrid, Spain

Background

Our aims were: 1.) to compare the characteristics of SARS-CoV-2 infection in IBD patients in the second and third wave with respect to the results published in our site in the first wave (I. Guerra et al. Inflamm Bowel Dis. 2021 Jan 1;27(1):25-33) and 2.) to compare the date of the second and third wave with data of general population from the Autonomous Community of Madrid

Methods

Cohort, observational study in IBD patients followed in our IBD Unit with SARS-CoV-2 infection between March 2020 and May 2020 (first wave) and between July 2020 to March 2021 (second-third wave). All data were collected by telephone interview and reviewing the electronical medical records

Results

The demographic characteristics of the patients included are shown in Table 1.

Table 1 First Wave(Nº of cases 28/805) Second-Third wave(Nº of cases 51/805) P-Value
Mean age 55±14 y45±13 y0.004
Gender (female) 13 (46.4%) 29 (56.9%) 0.61
Type of IBD (Crohn’s disease) 11 (39.3%) 29 (56.9%) 0.38
Smoking (Yes) 1 (3.6%) 12 (23.5%) 0.048
Cormobilities (Yes) 17 (60.7%) 15 (29.4%) 0.09
IMM treatment (Yes) 10 (35.7%) 19 (37.3%) 0.92
Anti-TNF treatment (Yes) 5 (17.8%) 15 (29.4%) 0.27


Regarding clinical features of SARS-CoV-2 infection in both group of patients are represented in Table 2.

Table 2 First Wave(Nº of cases 28/805) Second-Third wave(Nº of cases 51/805) P-Value
Digestive symptoms 14 (50.0%) 22 (43.1%) 0.64
Cough 21 (75.0%) 13 (25.5%) 0.0096
Fever 24 (85.7%) 22 (43.1%) 0.07
Dyspnoea 13 (46.4%) 9 (17.6%) 0.045
Dysosmia/dysgeusia 17 (60.7%) 20 (39.2%) 0.11
Headache 17 (60.7%) 13 (25.5%) 0.04
Myalgia 11(36.3%) 10 (19.6%) 0.15
Severity (moderate-severe) 15 (53.6%) 6 (11.7%) 0.031
IUC admission 1 (3.5%) 0 (0%) 0.18
Mortality 1 (3.5%) 1 (2.0%) 0.61
Any treatment for COVID-19 infection (Yes) 15 (53.6%) 5 (9.8%) 0.0014
Temporary withdrawal of IBD treatment (Yes) 13 (46.4%) 6 (11.7%) 0.009


The severity of disease was not related to immunomodulators and/or biological treatments in both cohorts.

The number of COVID-19 cases by date in our IBD Unit in comparison with the cases in the Community of Madrid are shown in the Figure 1.



Conclusion

The patients diagnosed in the first wave were older and more symptomatic. Although the number of severe cases was higher in the first wave, influenced by the limited availability of tests in that period, no difference was found in mortality or in the percentage of ICU admissions.Severity of SARS-CoV-2 infection was not related to immunosuppression and in the second-third wave the IBD treatment was maintained more frequently.The distribution of cases in our series was in concordance with the data obtained in the general population.

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