P843 Intestinal microbiota changes according to disease activity in patients with ulcerative colitis
B. Barberio, E. Bertazzo, C. Marinelli, D. Massimi, M. Ghisa, A. Gubbiotti, C. Casadei, G. Lorenzon, F. Zingone, R. D’Incà, E.V. Savarino
University of Padua, Department of Surgery- Oncology and Gastroenterology, Padua, Italy
Background
Intestinal dysbiosis has been consistently described in patients with inflammatory bowel disease (IBD), particularly about changes in gut microbiota’s composition and reduction of biodiversity. The identification of a characteristic microbiota could bring to a better understanding of ulcerative colitis (UC) pathogenesis and to find possible microbial markers of disease activity in UC. The primary purpose of our study has been to evaluate the different compositions of gut microbiota between subjects with UC and healthy controls and between patients in remission and patients with severe colitis.
Methods
A total of 64 subjects were enrolled: 18 with severe colitis (sUC), 22 UC patients in remission (rUC) and 24 healthy controls (HC). Faecal samples were analysed using the
Results
Significant statistical differences in relative frequencies of phyla exist between UC patients and HC: frequencies of the phyla Firmicutes (with a median of 48.10% in UC and of 34.31% in HC,
Conclusion
The difference between the gut microbiota of rUC and sUC patients is mainly the relative frequency of the phylum Proteobacteria, increased in sUC patients. The α-diversity is similar in these two groups, suggesting a limited role in the influence of the course of the disease.