ECCO News

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ECCO News keeps ECCO Members up-to-date on what is going on within the organisation and reports on IBD activities taking place within Europe. Since Spring 2006, ECCO News has maintained the flow of information between Members of the organisation. 

ECCO News is an important part of the European Crohn’s and Colitis Organisation’s ambition to create a European standard of IBD care and to promote knowledge and research in the field of IBD. ECCO Members automatically receive this publication four times a year. 

Latest ECCO News Content


11December2018

ECCO Grant Study Synopsis

Patrick van Rheenen, ECCO Grant Winner and Sjoukje Haisma, PhD candidate

Identification of rare genetic variants contributing to the development of childhood-onset IBD-PSC using parent-offspring trios

 

Patrick van RheenenPatrick van Rheenen
© Patrick van Rheenen

Primary Sclerosing Cholangitis (PSC) is a rare and severe disease leading to fibrotic destruction of the bile ducts. The majority of childhood-onset cases are associated with Inflammatory Bowel Disease, Ulcerative Colitis in particular.

Posted in ECCO News, Volume 13, Issue 4, Committee News, SciCom

11December2018

ECCO Grant Study Synopsis

Janneke N. Samsom, ECCO Grant Winner

TIGIT+CD38+ effector cells: New players in suppressing inflammation in IBD?

 

03 SciCom 5 5 Samson Janneke MASTER ECCO Grant synopsisJanneke N. Samsom 
© Janneke N. Samsom 

Background and Hypothesis

In Inflammatory Bowel Disease (IBD), T-cell reactivity against harmless microbial antigens drives chronic inflammation. After induction of remission, patients receive T-cell-suppressing maintenance treatment, which is effective in maintaining remission in some patients but not others. “T-cell immunoglobulin and ITIM domain” (TIGIT) is a novel inhibitor of T-cell activation. Preliminary experiments show that human circulating TIGIT-expressing CD38+ effector T cells are concomitantly enriched in the inhibitory molecules IL-10, PD-1 and CTLA-4. Crucially, frequencies of these cells were much reduced in a subgroup of paediatric IBD patients at disease onset and associated with reduced duration of clinical remission during follow-up.

We hypothesise that TIGIT+CD38+ effector T cells are functionally involved in immune regulation of microbial responses in the gastrointestinal tract.

Posted in ECCO News, Volume 13, Issue 4, Committee News, SciCom

11December2018

ECCO Grant Study Synopsis

Stefan Koch, ECCO Grant Winner

Regulation of intestinal epithelial homeostasis by Cyclin Y

 

03 SciCom 4 4 Koch Stefan MASTER ECCO Grant synopsis roundedStefan Koch
© Stefan Koch

Aim of Research

Genetic predisposition contributes to the development of Inflammatory Bowel Diseases (IBD). Prior GWAS studies have identified numerous IBD risk loci, but most of them have no assigned function to date. The aim of this study is to explore the role of the IBD risk gene CCNY, encoding the Wnt signalling activator Cyclin Y, in intestinal homeostasis and wound repair.

Because Wnt signalling is essential for the maintenance of intestinal epithelial stem cells, we anticipate that CCNY mutations impair intestinal Wnt signalling and thereby reduce epithelial regeneration during colitis.

Posted in ECCO News, Volume 13, Issue 4, Committee News, SciCom

11December2018

ECCO Grant Study Synopsis

Timon Adolph, ECCO Grant Winner

The regulation and function of epithelial Glutathione Peroxidase 4 in Inflammatory Bowel Disease  

 

03 SciCom 3 3 Adolph Timon MASTER ECCO picture roundedTimon Adolph
© Timon Adolph

Aim of Research

Glutathione peroxidase 4 (GPX4) controls a specialised regulated form of cell death termed ferroptosis. Research supported by this ECCO Grant aims at investigating the regulation and function of GPX4 in intestinal epithelial cells (IECs) from patients with Crohn’s Disease (CD) and Ulcerative Colitis (UC). This project aims to establish a role for ferroptosis and lipid peroxidation in IBD and to clarify the function of GPX4 in Crohn’s Disease.

Posted in ECCO News, Volume 13, Issue 4, Committee News, SciCom

11December2018

ECCO Grant Study Synopsis

Sare Verstockt, ECCO Grant Winner

Using exosomes to gain insights into the early phase of Crohn’s Disease  

 

03 SciCom 2 2 Verstockt Sare MASTER ECCO Grant synopsis rounded Sare Verstockt
© Sare Verstockt

Aim of Research

Crohn’s Disease (CD) is characterised by chronic inflammation of the gut. Treatment usually involves drug therapy or surgery with the goal of reducing inflammation and inducing and maintaining steroid-free remission and mucosal healing. A more intensive treatment early in the disease course leads to better outcomes. However, the time between symptoms and diagnosis is often years.

The aims of this project are to identify (a) the triggers present at the onset of CD, allowing (pointers for) new therapies, and (b) molecular markers that can help diagnose CD as early as possible. Given that exosomes provide a rich genetic profile reflecting their cellular origin, we are focussing on exosomal markers.

 

Posted in ECCO News, Volume 13, Issue 4, Committee News, SciCom

11December2018

ECCO Grant Study Synopsis

Aline van Acker, ECCO Grant Winner

Innate lymphoid cells in Paediatric Inflammatory Bowel Disease  

 

03 SciCom 1 1 Van Acker Aline Photo roundedAline van Acker
© Aline van Acker

The incidence of paediatric IBD (PIBD) is on the rise. However, the underlying aetiology of PIBD remains largely unknown, indicating the dire need for more knowledge on the mechanisms driving this disease. Innate lymphoid cells (ILCs) constitute an important component of the mucosal immune system. Recent years have seen an increase in ILC knowledge, with numerous publications highlighting the importance of ILCs in murine and adult IBD development and progression.

In this project, we aim to elucidate ILC heterogeneity and function specifically in PIBD. In practice, single-cell suspensions are isolated from blood and colon biopsies of PIBD and non-PIBD patients admitted to the Paediatric Gastroenterology, Hepatology and Nutrition Unit at Karolinska University Hospital, Stockholm, Sweden or the Department of Clinical Research and Education at Södra Hospital, Stockholm.

Posted in ECCO News, Volume 13, Issue 4, Committee News, SciCom

11December2018

ECCO’19 Scientific Programme Preview

Pieter Hindryckx, ECCO News Associate Editor

Pieter Hindryckx Pieter Hindryckx
© ECCO

For the 14th edition of the ECCO Congress we return to the venue of the 2014 Congress: the Bella Center in the city of Copenhagen, Denmark.

The central theme of the 2019 Congress is “Research drives clinical care”, reflecting a well-balanced cocktail comprising the latest advances in basic and clinical research in IBD and their (potential) implications for daily clinical practice.  

Posted in ECCO News, Volume 13, Issue 4, Committee News, ECCO'19

11December2018

Letter from the ECCO President

Silvio Danese, ECCO President

Silvio Danese
Silvio Danese
© ECCO

Dear ECCO friends,

While we wait a few more months for our ECCO Congress 2019 and are getting ready to face another cold winter, I would like to give you an update on the latest ECCO Initiatives for the meeting, which are the result of much hard work by all the ECCO Committees.

Posted in ECCO News, Volume 13, Issue 4, Letters from the ECCO President

04October2018

Interview with N-ECCO National Representative

17 Cyprus Anastasia N. Nicolaou
Anastasia N. Nicolaou
© Anastasia N. Nicolaou

Cyprus   Cyprus

N-ECCO National Representative: Anastasia N. Nicolaou
Job Title:
GI - IBD Nurse


What influenced your decision to apply for the role of N-ECCO National Representative for your country?
I work in a centre which sees a large number of IBD patients and therefore I felt the need to have a more active role. I have also applied for a PhD in a local university which has a research programme on IBD. 

Posted in ECCO News, Volume 13, Issue 3, ECCO Country Member Profiles, N-ECCO

04October2018

ECCO Country Member Profiles: Sweden

Ann-Sofie Backman, Michael Eberhardson, ECCO National Representatives, Sweden

Sweden   Sweden

Name of group: Swedish Organisation for the Study of IBD
Number of active members: 45
Number of meetings per year: Two main meetings plus numerous project meetings
President and Secretary: 
        Pär Myrelid, President
        Franscesca Bresso, Secretary
National Representatives: 
        Ann-Sofie Backman
        Michael Eberhardson

Joined ECCO in:  2004
Incidence of IBD in the country (if available): 
0.64% prevalence

Posted in ECCO News, Volume 13, Issue 3, ECCO Country Member Profiles