Fellowships & Grants Synopsis Reports

11December2018

ECCO Grant Study Synopsis: Timon Adolph

Timon Adolph, ECCO Grant Winner

The regulation and function of epithelial Glutathione Peroxidase 4 in Inflammatory Bowel Disease  

 

03 SciCom 3 3 Adolph Timon MASTER ECCO picture roundedTimon Adolph
© Timon Adolph

Aim of Research

Glutathione peroxidase 4 (GPX4) controls a specialised regulated form of cell death termed ferroptosis. Research supported by this ECCO Grant aims at investigating the regulation and function of GPX4 in intestinal epithelial cells (IECs) from patients with Crohn’s Disease (CD) and Ulcerative Colitis (UC). This project aims to establish a role for ferroptosis and lipid peroxidation in IBD and to clarify the function of GPX4 in Crohn’s Disease.

Posted in Fellowships & Grants Synopsis Reports, ECCO News, Committee News, SciCom, Volume 13, Issue 4

11December2018

ECCO Grant Study Synopsis: Sare Verstockt

Sare Verstockt, ECCO Grant Winner

Using exosomes to gain insights into the early phase of Crohn’s Disease  

 

03 SciCom 2 2 Verstockt Sare MASTER ECCO Grant synopsis rounded Sare Verstockt
© Sare Verstockt

Aim of Research

Crohn’s Disease (CD) is characterised by chronic inflammation of the gut. Treatment usually involves drug therapy or surgery with the goal of reducing inflammation and inducing and maintaining steroid-free remission and mucosal healing. A more intensive treatment early in the disease course leads to better outcomes. However, the time between symptoms and diagnosis is often years.

The aims of this project are to identify (a) the triggers present at the onset of CD, allowing (pointers for) new therapies, and (b) molecular markers that can help diagnose CD as early as possible. Given that exosomes provide a rich genetic profile reflecting their cellular origin, we are focussing on exosomal markers.

 

Posted in Fellowships & Grants Synopsis Reports, ECCO News, Committee News, SciCom, Volume 13, Issue 4

11December2018

ECCO Grant Study Synopsis: Aline van Acker

Aline van Acker, ECCO Grant Winner

Innate lymphoid cells in Paediatric Inflammatory Bowel Disease  

 

03 SciCom 1 1 Van Acker Aline Photo roundedAline van Acker
© Aline van Acker

The incidence of paediatric IBD (PIBD) is on the rise. However, the underlying aetiology of PIBD remains largely unknown, indicating the dire need for more knowledge on the mechanisms driving this disease. Innate lymphoid cells (ILCs) constitute an important component of the mucosal immune system. Recent years have seen an increase in ILC knowledge, with numerous publications highlighting the importance of ILCs in murine and adult IBD development and progression.

In this project, we aim to elucidate ILC heterogeneity and function specifically in PIBD. In practice, single-cell suspensions are isolated from blood and colon biopsies of PIBD and non-PIBD patients admitted to the Paediatric Gastroenterology, Hepatology and Nutrition Unit at Karolinska University Hospital, Stockholm, Sweden or the Department of Clinical Research and Education at Södra Hospital, Stockholm.

Posted in Fellowships & Grants Synopsis Reports, ECCO News, Committee News, SciCom, Volume 13, Issue 4

04October2018

ECCO Fellowship Study Synopsis: Danping Zheng

Danping Zheng, ECCO Fellow 2018

The role of Nlrp9b in regulating intestinal inflammation  

 

03 SciCom 5a MASTER Danping Zheng
Danping Zheng
© 
Danping Zheng

Aim of the research

Innate immune signalling pathways, including inflammasome-forming Noll-like receptors (NLR), are thought to mediate the risk of Inflammatory Bowel Disease (IBD) since this system acts as the first line of defence in the recognition of enteric pathogens. In our preliminary study, we identified a new NLR member, Nlrp9b, whose role in the pathogenesis of IBD remains to be clarified. The aim of our study is to investigate the role of Nlrp9b in regulating intestinal inflammation and the underlying mechanisms.

Posted in Fellowships & Grants Synopsis Reports, ECCO News, Committee News, SciCom, Volume 13, Issue 3

04October2018

ECCO Fellowship Study Synopsis: Sudharshan Elangovan

Sudharshan Elangovan, ECCO Fellow 2018

TSG-6, a potential new therapeutic target in fistulising Crohn’s Disease  

 

03 SciCom 3a MASTER Sudharshan Elangovan
Sudharshan Elangovan
© 
Sudharshan Elangovan

Background

Fistulising Crohn’s Disease (CD) represents a demanding, complex, and as yet unresolved issue, characterised by lesions with active pus drainage through the external fistula openings. Despite advances in understanding of the pathophysiology, to date there are no specific and efficient therapies or molecular markers for its treatment or prevention. TNF-α stimulated gene/protein-6 (TSG-6), an anti-inflammatory protein produced in response to signals from injured tissue, has been shown to exert remarkable therapeutic effects on colitis and on wound healing in various disease models.

Posted in Fellowships & Grants Synopsis Reports, ECCO News, Committee News, SciCom, Volume 13, Issue 3

04October2018

ECCO Fellowship Study Synopsis: Sales Ibiza

Sales Ibiza, ECCO Fellow 2018

Monocyte-derived macrophages as crucial players in the resolution of inflammation and tissue repair in Inflammatory Bowel Disease  

 

03 SciCom 2a MASTER Ibiza Martinez Sales image
Sales Ibiza
© 
Sales Ibiza

Background

Inflammatory Bowel Disease (IBD) is characterised by chronic inflammation of the gastrointestinal tract leading to debilitating symptoms. No curative therapies are currently available for IBD, with the consequence that the disease has a significant impact on the emotional, financial and social status of patients and their families. Although most studies conducted on IBD over the past few decades have investigated abnormal adaptive immunity, the focus has recently shifted towards alterations in innate immune response. Recent data suggest a causal link between defects in the resolution of inflammation associated with impaired bacterial clearance, excessive cytokine secretion and altered monocyte-macrophage (Mφ) transition in patients with IBD.

Posted in Fellowships & Grants Synopsis Reports, ECCO News, Committee News, SciCom, Volume 13, Issue 3

04October2018

ECCO Fellowship Study Synopsis: Mathieu Uzzan

Mathieu Uzzan, ECCO Fellow 2018

Deciphering the gut-specific B cell response in Inflammatory Bowel Disease (IBD)  

 

03 SciCom 6a MASTER Mathieu UzzanMathieu Uzzan
© 
Mathieu Uzzan

Aim of the research

Given that there is a large complement of mucosal B cells that plays a pivotal role in the regulation of the microbiome and in mucosal homeostasis, it is likely that they play an important but yet understudied role in the pathogenesis of IBD. Therefore, we hypothesize that mucosal inflammation as seen in IBD will induce a B cell response with homeostatic and perhaps pathogenic properties.

Posted in Fellowships & Grants Synopsis Reports, ECCO News, Committee News, SciCom, Volume 13, Issue 3

04October2018

ECCO Fellowship Study Synopsis: Federica Branchi

Federica Branchi, ECCO Fellow 2018

Investigation of the role of Par4-associated cell polarity and associated barrier defects in Inflammatory Bowel Diseases  

 

03 SciCom 1a MASTER Federica Branchi fotoFederica Branchi
© 
Federica Branchi

Aim of the research

In Inflammatory Bowel Diseases (IBD), epithelial barrier defects occur as a consequence of chronic inflammation. Recent research has suggested that cell polarity alterations may be upstream of barrier defects and additionally play a role in IBD-associated carcinogenesis (colitis-associated and small intestinal carcinoma). Par4 is a gene encoding a protein crucial in the development of cell polarity. LKB1, its human homologue, is mutated in Peutz-Jeghers syndrome (PJS), a genetic condition characterised by a higher risk of epithelial cancers. Considering the pivotal role of Par4/LKB1 in the development of epithelial cell polarity, this project aims to assess its involvement in IBD-associated barrier defects and carcinogenesis.

Posted in Fellowships & Grants Synopsis Reports, ECCO News, Committee News, SciCom, Volume 13, Issue 3

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