Fellowships & Grants Synopsis Reports

04October2018

ECCO Fellowship Study Synopsis: Danping Zheng

Danping Zheng, ECCO Fellow 2018

The role of Nlrp9b in regulating intestinal inflammation  

 

03 SciCom 5a MASTER Danping Zheng
Danping Zheng
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Danping Zheng

Aim of the research

Innate immune signalling pathways, including inflammasome-forming Noll-like receptors (NLR), are thought to mediate the risk of Inflammatory Bowel Disease (IBD) since this system acts as the first line of defence in the recognition of enteric pathogens. In our preliminary study, we identified a new NLR member, Nlrp9b, whose role in the pathogenesis of IBD remains to be clarified. The aim of our study is to investigate the role of Nlrp9b in regulating intestinal inflammation and the underlying mechanisms.

Posted in ECCO News, Committee News, SciCom, Fellowships & Grants Synopsis Reports, Volume 13, Issue 3

04October2018

ECCO Fellowship Study Synopsis: Sudharshan Elangovan

Sudharshan Elangovan, ECCO Fellow 2018

TSG-6, a potential new therapeutic target in fistulising Crohn’s Disease  

 

03 SciCom 3a MASTER Sudharshan Elangovan
Sudharshan Elangovan
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Sudharshan Elangovan

Background

Fistulising Crohn’s Disease (CD) represents a demanding, complex, and as yet unresolved issue, characterised by lesions with active pus drainage through the external fistula openings. Despite advances in understanding of the pathophysiology, to date there are no specific and efficient therapies or molecular markers for its treatment or prevention. TNF-α stimulated gene/protein-6 (TSG-6), an anti-inflammatory protein produced in response to signals from injured tissue, has been shown to exert remarkable therapeutic effects on colitis and on wound healing in various disease models.

Posted in ECCO News, Committee News, SciCom, Fellowships & Grants Synopsis Reports, Volume 13, Issue 3

04October2018

ECCO Fellowship Study Synopsis: Sales Ibiza

Sales Ibiza, ECCO Fellow 2018

Monocyte-derived macrophages as crucial players in the resolution of inflammation and tissue repair in Inflammatory Bowel Disease  

 

03 SciCom 2a MASTER Ibiza Martinez Sales image
Sales Ibiza
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Sales Ibiza

Background

Inflammatory Bowel Disease (IBD) is characterised by chronic inflammation of the gastrointestinal tract leading to debilitating symptoms. No curative therapies are currently available for IBD, with the consequence that the disease has a significant impact on the emotional, financial and social status of patients and their families. Although most studies conducted on IBD over the past few decades have investigated abnormal adaptive immunity, the focus has recently shifted towards alterations in innate immune response. Recent data suggest a causal link between defects in the resolution of inflammation associated with impaired bacterial clearance, excessive cytokine secretion and altered monocyte-macrophage (Mφ) transition in patients with IBD.

Posted in ECCO News, Committee News, SciCom, Fellowships & Grants Synopsis Reports, Volume 13, Issue 3

04October2018

ECCO Fellowship Study Synopsis: Mathieu Uzzan

Mathieu Uzzan, ECCO Fellow 2018

Deciphering the gut-specific B cell response in Inflammatory Bowel Disease (IBD)  

 

03 SciCom 6a MASTER Mathieu UzzanMathieu Uzzan
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Mathieu Uzzan

Aim of the research

Given that there is a large complement of mucosal B cells that plays a pivotal role in the regulation of the microbiome and in mucosal homeostasis, it is likely that they play an important but yet understudied role in the pathogenesis of IBD. Therefore, we hypothesize that mucosal inflammation as seen in IBD will induce a B cell response with homeostatic and perhaps pathogenic properties.

Posted in ECCO News, Committee News, SciCom, Fellowships & Grants Synopsis Reports, Volume 13, Issue 3

04October2018

ECCO Fellowship Study Synopsis: Federica Branchi

Federica Branchi, ECCO Fellow 2018

Investigation of the role of Par4-associated cell polarity and associated barrier defects in Inflammatory Bowel Diseases  

 

03 SciCom 1a MASTER Federica Branchi fotoFederica Branchi
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Federica Branchi

Aim of the research

In Inflammatory Bowel Diseases (IBD), epithelial barrier defects occur as a consequence of chronic inflammation. Recent research has suggested that cell polarity alterations may be upstream of barrier defects and additionally play a role in IBD-associated carcinogenesis (colitis-associated and small intestinal carcinoma). Par4 is a gene encoding a protein crucial in the development of cell polarity. LKB1, its human homologue, is mutated in Peutz-Jeghers syndrome (PJS), a genetic condition characterised by a higher risk of epithelial cancers. Considering the pivotal role of Par4/LKB1 in the development of epithelial cell polarity, this project aims to assess its involvement in IBD-associated barrier defects and carcinogenesis.

Posted in ECCO News, Committee News, SciCom, Fellowships & Grants Synopsis Reports, Volume 13, Issue 3