Articles tagged with: Y-ECCO Literature Review


Y-ECCO Literature Review: Raquel Oliveira

Raquel Oliveira

Dysbiosis and associated stool features improve prediction of response to biological therapy in inflammatory bowel disease

Caenepeel C, Falony G, Machiels K, et al.

Gastroenterology 2024;166:483–495.

Raquel Oliveira
© Raquel Oliveira


The gut microbiota of patients with Inflammatory Bowel Disease (IBD) may have a role in disease aetiology and course [1]. Patients with IBD often have dysbiotic microbiota, with lower microbial diversity and cell counts, with both absolute and relative abundance of commensal microorganisms [2, 3]. Conversely, during remission following anti-inflammatory therapy, the gut microbiota has been observed to shift to a more eubiosis-like composition [3–6]. Furthermore, lower proportions of taxa with pro-inflammatory properties and mucus-degrading bacteria, as well as higher proportions of short-chain fatty acid-producing bacteria, have been associated with a higher likelihood of favourable outcomes with medical treatment [3, 5, 6]. In this study, Caenepeel and colleagues monitored changes in intestinal microbiota and stool features in order to develop and validate a predictive model to assist clinicians in determining a patient-specific therapeutic strategy.

Posted in ECCO News, Y-ECCO Literature Reviews, Committee News, Volume 19, Issue 2, Y-ECCO